Angiotensin II induces NF-κB, JNK and p38 MAPK activation in monocytic cells and will increase matrix metalloproteinase-9 expression in a PKC- andRho kinase-dependent method.
- Angiotensin II (ANG II), the primary effector of the renin-angiotensin system, is implicated in endothelial permeability, recruitment and activation of the immune cells, and in addition vascular transforming by way of induction of inflammatory genes. Matrix metalloproteinases (MMPs) are thought of to be necessary inflammatory elements.
HYDROXYSTILBAMIDINE BIS(METHANESULFONATE)
- Elucidation of ANG II signaling pathways and of possible cross-talks between their parts is crucial for the event of environment friendly inhibitory medicines. The present research investigates the inflammatory signaling pathmethods activated by ANG II in cultures of human monocytic U-937 cells, and the results of particular pharmacological inhibitors of signaling intermediates on MMP-9 gene (MMP-9) expression and exercise.
- MMP-9 expression was decided by real-time PCR and supernatants had been analyzed for MMP-9 exercise by ELISA and zymography strategies. A multi-target ELISA package was employed to judge IκB, NF-κB, JNK, p38, and STAT3 activation following remedies.
- Stimulation with ANG II (100 nM) considerably elevated MMP-9 expression and exercise, and in addition activated NF-κB, JNK, and p38 by 3.8-, 2.8- and a pair of.2-fold, respectively (P < 0.01). ANG II-induced MMP-9 expression was considerably diminished by 75 and 67%, respectively, by co-incubation of the cells with a selective inhibitor of protein kinase C (GF109203X, 5 µM) or of rho kinase (Y-27632, 15 µM), however not with inhibitors of phosphoinositide 3-kinase (wortmannin, 200 nM), tyrosine kinases (genistein, 100 µM) or of reactive oxygen species (α-tocopherol, 100 µM).
Angiotensin 1-9 (Ang1-9) Monoclonal Antibody (Human), Biotinylated
- Thus, protein kinase C and Rho kinase are necessary parts of the inflammatory signaling pathways activated by ANG II to extend MMP-9 expression in monocytic cells. Each signaling molecules might represent potential targets for efficient administration of irritation.
![]() Imatinib, Methanesulfonate Salt, >99% |
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BC040-101 | GenDepot | 1g | EUR 232 |
![]() Imatinib, Methanesulfonate Salt, >99% |
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BC040-102 | GenDepot | 2g | EUR 300 |
![]() Imatinib, Methanesulfonate Salt, >99% |
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BC040-105 | GenDepot | 5g | EUR 421 |
![]() Imatinib, Methanesulfonate Salt, >99% |
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BC040-500 | GenDepot | 500mg | Ask for price |
![]() Colistin Methanesulfonate (sodium salt) |
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C3046-1000 | ApexBio | 1 g | EUR 174 |
![]() Colistin Methanesulfonate (sodium salt) |
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C3046-5000 | ApexBio | 5 g | EUR 612 |
![]() Obatoclax (Mesylate) |
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HY-10969 | MedChemExpress | 100mg | EUR 546 |
![]() Obatoclax (GX15-070) |
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E1KS1057 | EnoGene | 5 mg | EUR 1111 |
![]() Abemaciclib (methanesulfonate) |
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HY-16297 | MedChemExpress | 500mg | EUR 452 |
![]() Tricaine methanesulfonate |
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GE5936-10G | Glentham Life Sciences | 10 g | EUR 57 |
![]() Tricaine methanesulfonate |
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GE5936-25G | Glentham Life Sciences | 25 g | EUR 82 |
![]() Tricaine methanesulfonate |
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GE5936-50G | Glentham Life Sciences | 50 g | EUR 118 |
![]() Tricaine methanesulfonate |
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GE5936-5G | Glentham Life Sciences | 5 g | EUR 47 |
![]() Ethyl methanesulfonate |
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GX0446-100G | Glentham Life Sciences | 100 g | EUR 261 |
![]() Ethyl methanesulfonate |
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GX0446-10G | Glentham Life Sciences | 10 g | EUR 74 |
![]() Ethyl methanesulfonate |
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GX0446-25G | Glentham Life Sciences | 25 g | EUR 118 |
![]() Ethyl methanesulfonate |
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GX0446-5G | Glentham Life Sciences | 5 g | EUR 54 |
![]() Silver methanesulfonate |
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GX5020-25G | Glentham Life Sciences | 25 g | EUR 174 |
![]() Silver methanesulfonate |
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GX5020-5G | Glentham Life Sciences | 5 g | EUR 71 |
![]() Ethyl methanesulfonate |
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20-abx186442 | Abbexa |
|
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![]() Pridinol Methanesulfonate |
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A8507-1000 | ApexBio | 1 g | EUR 431 |
![]() Pridinol Methanesulfonate |
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A8507-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 108 |
![]() Pridinol Methanesulfonate |
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A8507-50 | ApexBio | 50 mg | EUR 128 |
![]() Pridinol Methanesulfonate |
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A8507-5000 | ApexBio | 5 g | EUR 999 |
![]() Obatoclax mesylate (GX15-070) |
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A4194-10 | ApexBio | 10 mg | EUR 276 |
![]() Obatoclax mesylate (GX15-070) |
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A4194-100 | ApexBio | 100 mg | EUR 1279 |
![]() Obatoclax mesylate (GX15-070) |
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A4194-25 | ApexBio | 25 mg | EUR 485 |
![]() Obatoclax mesylate (GX15-070) |
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A4194-5 | ApexBio | 5 mg | EUR 177 |
![]() Obatoclax mesylate (GX15-070) |
|||
A4194-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 203 |
![]() Obatoclax mesylate (GX15-070) |
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A4194-50 | ApexBio | 50 mg | EUR 664 |
![]() Obatoclax mesylate (GX15-070) |
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A4194-S | ApexBio | Evaluation Sample | EUR 81 |
![]() BCX 1470 (methanesulfonate) |
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HY-50875 | MedChemExpress | 10mM/1mL | EUR 580 |
![]() Tariquidar (methanesulfonate, hydrate) |
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HY-10550A | MedChemExpress | 100mg | EUR 612 |
![]() Hydroxystilbamidine bis(methanesulfonate) |
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HY-108166A | MedChemExpress | 5mg | EUR 533 |
![]() PF-06424439 (methanesulfonate) |
|||
HY-108341A | MedChemExpress | 10mM/1mL | EUR 146 |
![]() PF-04217903 (methanesulfonate) |
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HY-12017A | MedChemExpress | 10mM/1mL | EUR 156 |
![]() Colistin sodium methanesulfonate |
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GA2961-1G | Glentham Life Sciences | 1 g | EUR 126 |
![]() Colistin sodium methanesulfonate |
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GA2961-5G | Glentham Life Sciences | 5 g | EUR 293 |
![]() Colistin Sodium Methanesulfonate |
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C073-10G | TOKU-E | 10 g | EUR 820 |
![]() Colistin Sodium Methanesulfonate |
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C073-1G | TOKU-E | 1 g | EUR 135 |
![]() Colistin Sodium Methanesulfonate |
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C073-5G | TOKU-E | 5 g | EUR 440 |
![]() 2-Chloroethyl methanesulfonate |
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20-abx183170 | Abbexa |
|
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![]() PF-04217903 methanesulfonate |
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A3712-100 | ApexBio | 100 mg | EUR 595 |
![]() PF-04217903 methanesulfonate |
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A3712-25 | ApexBio | 25 mg | EUR 293 |
![]() PF-04217903 methanesulfonate |
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A3712-5 | ApexBio | 5 mg | EUR 131 |
![]() Tariquidar methanesulfonate, hydrate |
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A3859-10 | ApexBio | 10 mg | EUR 189 |
![]() Tariquidar methanesulfonate, hydrate |
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A3859-50 | ApexBio | 50 mg | EUR 444 |
![]() Ethyl 3-Aminobenzoate (methanesulfonate) |
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C3619-25000 | ApexBio | 25 g | EUR 128 |
![]() Ethyl 3-Aminobenzoate (methanesulfonate) |
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C3619-100000 | ApexBio | 100 g | EUR 318 |
![]() Ethyl 3-Aminobenzoate (methanesulfonate) |
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C3619-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 113 |
![]() Ethyl 3-Aminobenzoate (methanesulfonate) |
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C3619-50000 | ApexBio | 50 g | EUR 195 |
![]() Ro 31-8220 methanesulfonate |
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1946-1 | Biovision | EUR 137 |
![]() Ro 31-8220 methanesulfonate |
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1946-5 | Biovision | EUR 381 |
![]() Bile salt |
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BB0225 | Bio Basic | 25g | EUR 79.58 |
![]() Cromolyn sodium salt |
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SB0843 | Bio Basic | 5g | EUR 65.66 |
![]() Methotrexate sodium salt |
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M031-250MG | TOKU-E | 250 mg | EUR 117 |
![]() Monensin Sodium Salt |
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M083-1G | TOKU-E | 1 g | EUR 71 |
![]() Monensin Sodium Salt |
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M083-5x1G | TOKU-E | 5 x 1 g | EUR 159 |
![]() Morantel (+)-tartrate salt |
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M084-1G | TOKU-E | 1 g | EUR 215 |
![]() Morantel (+)-tartrate salt |
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M084-250MG | TOKU-E | 250 mg | EUR 92 |
![]() Morantel citrate salt |
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M086-100MG | TOKU-E | 100 mg | EUR 74 |
![]() MES, sodium salt |
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MB0611 | Bio Basic | 50g | EUR 74.36 |
![]() MOPSO, sodium salt |
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MDB0095 | Bio Basic | 25g | EUR 63.92 |
![]() MOPS, sodium salt |
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MDB360S | Bio Basic | 100g | EUR 89.15 |
![]() Mupirocin lithium salt |
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M023-100MG | TOKU-E | 100 mg | EUR 380 |
![]() Mupirocin lithium salt |
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M023-500MG | TOKU-E | 500 mg | EUR 762 |
![]() Pentamidine isethionate salt |
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P114-1G | TOKU-E | 1 g | EUR 135 |
![]() Pentamidine isethionate salt |
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P114-250MG | TOKU-E | 250 mg | EUR 82 |
![]() Entacapone (sodium salt) |
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HY-14280A | MedChemExpress | 10mg | EUR 119 |
![]() Grazoprevir potassium salt |
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HY-15298A | MedChemExpress | 5mg | EUR 173 |
![]() Grazoprevir sodium salt |
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HY-15298C | MedChemExpress | 10mg | EUR 243 |
![]() Sacubitril hemicalcium salt |
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HY-15407A | MedChemExpress | 5mg | EUR 119 |
Angiotensin II induces NF-κB, JNK and p38 MAPK activation in monocytic cells and will increase matrix metalloproteinase-9 expression in a PKC- andRho kinase-dependent method.
- Angiotensin II (ANG II), the primary effector of the renin-angiotensin system, is implicated in endothelial permeability, recruitment and activation of the immune cells, and in addition vascular transforming by way of induction of inflammatory genes. Matrix metalloproteinases (MMPs) are thought of to be necessary inflammatory elements.
Mouse pre-microRNA Expression Assemble mir-9-1
- Elucidation of ANG II signaling pathways and of potential cross-talks between their components is crucial for the event of environment friendly inhibitory medicines.
- The present research investigates the inflammatory signaling pathways activated by ANG II in cultures of human monocytic U-937 cells, and the results of particular pharmacological inhibitors of signaling intermediates on MMP-9 gene (MMP-9) expression and exercise. MMP-9 expression was decided by real-time PCR and supernatants had been analyzed for MMP-9 exercise by ELISA and zymography strategies.
- A multi-target ELISA package was employed to judge IκB, NF-κB, JNK, p38, and STAT3 activation following remedies. Stimulation with ANG II (100 nM) considerably elevated MMP-9 expression and exercise, and in addition activated NF-κB, JNK, and p38 by 3.8-, 2.8- and a pair of.2-fold, respectively (P < 0.01).
![]() Human Angiotensin 1-9 (Ang1-9) ELISA Kit |
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DLR-Ang1-9-Hu-48T | DL Develop | 48T | EUR 501 |
![]() Human Angiotensin 1-9 (Ang1-9) ELISA Kit |
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DLR-Ang1-9-Hu-96T | DL Develop | 96T | EUR 651 |
![]() Human Angiotensin 1-9 (Ang1-9) ELISA Kit |
|||
RD-Ang1-9-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 503 |
![]() Human Angiotensin 1-9 (Ang1-9) ELISA Kit |
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RD-Ang1-9-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 697 |
![]() Human Angiotensin 1-9 (Ang1-9) ELISA Kit |
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RDR-Ang1-9-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 525 |
![]() Human Angiotensin 1-9 (Ang1-9) ELISA Kit |
|||
RDR-Ang1-9-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 729 |
![]() Angiotensin 1-9 (Ang1-9) Monoclonal Antibody (Human) |
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4-MAT844Hu21 | Cloud-Clone |
|
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![]() Angiotensin 1-9 (Ang1-9) Antibody |
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20-abx132109 | Abbexa |
|
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![]() Angiotensin 1-9 (Ang1-9) Monoclonal Antibody (Human), APC |
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4-MAT844Hu21-APC | Cloud-Clone |
|
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![]() Angiotensin 1-9 (Ang1-9) Monoclonal Antibody (Human), Biotinylated |
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4-MAT844Hu21-Biotin | Cloud-Clone |
|
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![]() Angiotensin 1-9 (Ang1-9) Monoclonal Antibody (Human), Cy3 |
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4-MAT844Hu21-Cy3 | Cloud-Clone |
|
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![]() Angiotensin 1-9 (Ang1-9) Monoclonal Antibody (Human), FITC |
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4-MAT844Hu21-FITC | Cloud-Clone |
|
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![]() Angiotensin 1-9 (Ang1-9) Monoclonal Antibody (Human), HRP |
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4-MAT844Hu21-HRP | Cloud-Clone |
|
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![]() Angiotensin 1-9 (Ang1-9) Monoclonal Antibody (Human), PE |
|||
4-MAT844Hu21-PE | Cloud-Clone |
|
|
![]() Rat Angiotensin 1-9(Ang1-9) |
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QY-E11784 | Qayee Biotechnology | 96T | EUR 374 |
![]() Angiotensin 1-9 (Ang1-9) Monoclonal Antibody (Human), APC-Cy7 |
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4-MAT844Hu21-APC-Cy7 | Cloud-Clone |
|
|
![]() Mouse Angiotensin 1-9 (Ang1-9) ELISA Kit |
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abx353312-96tests | Abbexa | 96 tests | EUR 786 |
![]() Angiotensin 1-9 (Ang1-9) CLIA Kit |
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20-abx490554 | Abbexa |
|
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![]() Angiotensin 1-9 (Ang1-9) ELISA Kit |
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20-abx258341 | Abbexa |
|
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![]() Human Angiotensin 1-9 (Ang1-9) ELISA Kit |
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20-abx150652 | Abbexa |
|
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![]() Human Angiotensin 1-9 (Ang1-9) ELISA Kit |
|||
abx575059-96tests | Abbexa | 96 tests | EUR 668 |
![]() Human Angiotensin 1-9 (Ang1-9)ELISA Kit |
|||
201-12-2829 | SunredBio | 96 tests | EUR 440 |
![]() Human Angiotensin 1-9 (Ang1-9) CLIA Kit |
|||
20-abx490553 | Abbexa |
|
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![]() Rat Angiotensin 1-9 (Ang1-9) ELISA Kit |
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abx257809-96tests | Abbexa | 96 tests | EUR 746 |
![]() Human Angiotensin 1-9 (Ang1-9) Peptide (OVA) |
|||
20-abx655870 | Abbexa |
|
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![]() Human Angiotensin 1-9 (Ang1-9) ELISA Kit |
|||
CET844Hu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 4993.3 |
![]() Human Angiotensin 1-9 (Ang1-9) ELISA Kit |
|||
CET844Hu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 498.86 |
![]() Human Angiotensin 1-9 (Ang1-9) ELISA Kit |
|||
CET844Hu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 669.8 |
![]() Human Angiotensin 1-9 (Ang1-9) ELISA Kit |
|||
CET844Hu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 2714.1 |
![]() Human Angiotensin 1-9 (Ang1-9) ELISA Kit |
|||
4-CET844Hu | Cloud-Clone |
|
|
![]() Human Angiotensin 1-9(Ang1-9)ELISA Kit |
|||
QY-E00730 | Qayee Biotechnology | 96T | EUR 361 |
![]() Rat Ang1-9(Angiotensin 1-9) ELISA Kit |
|||
ER1617 | FN Test | 96T | EUR 567.6 |
![]() ELISA kit for Mouse Ang1-9 (Angiotensin 1-9) Kit |
|||
E-EL-M2682 | Elabscience Biotech | 1 plate of 96 wells | EUR 534 |
![]() ELISA kit for Human Ang1-9 (Angiotensin 1-9) |
|||
ELK7609 | ELK Biotech | 1 plate of 96 wells | EUR 372 |
![]() ELISA kit for Human Ang1-9 (Angiotensin 1-9) |
|||
ELK7679 | ELK Biotech | 1 plate of 96 wells | EUR 432 |
![]() Multi-species Angiotensin 1-9 (Ang1-9) ELISA Kit |
|||
CET844Mi-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 5235.47 |
![]() Multi-species Angiotensin 1-9 (Ang1-9) ELISA Kit |
|||
CET844Mi-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 518.8 |
![]() Multi-species Angiotensin 1-9 (Ang1-9) ELISA Kit |
|||
CET844Mi-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 698.29 |
![]() Multi-species Angiotensin 1-9 (Ang1-9) ELISA Kit |
|||
CET844Mi-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 2842.31 |
![]() Multi-species Angiotensin 1-9 (Ang1-9) ELISA Kit |
|||
4-CET844Mi | Cloud-Clone |
|
|
![]() Ang1-9 ELISA Kit| Rat Angiotensin 1-9 ELISA Kit |
|||
EF018213 | Lifescience Market | 96 Tests | EUR 689 |
![]() 7095B 9 PASTEUR PIPET |
|||
7095B-9 | CORNING | 200/pk | EUR 70 |
![]() Individual Reaction Mix 9 |
|||
G065-9 | ABM | 200 reactions | EUR 167 |
![]() Mouse pre-microRNA Expression Construct mir-9-1 |
|||
MMIR-9-1-PA-1 | SBI | Bacterial Streak | EUR 684 |
![]() 7095D 9 PASTEUR PIPET BOROSILICATE |
|||
7095D-9 | CORNING | 200/pk | EUR 78 |
![]() Angiotensin (1-9) |
|||
5-00677 | CHI Scientific | 4 x 5mg | Ask for price |
![]() Mouse Brain Tissue Preparation Buffer 9: Normal Nerve Microglia |
|||
9-80132 | CHI Scientific | 1 x 100 ml | Ask for price |
![]() Anti-pro Caspase 9 Rabbit Monoclonal Antibody |
|||
M00080-1 | BosterBio | 100ug/vial | EUR 397 |
![]() Mouse Angiotensin (1- 9), ANG (1- 9) ELISA Kit |
|||
CELI-66004m | Lifescience Market | 96 Tests | EUR 865 |
![]() Angiotensin (1-9) Peptide |
|||
20-abx266137 | Abbexa |
|
|
![]() Angiotensin I (1-9) |
|||
H-5038.0025 | Bachem | 25.0mg | EUR 273 |
![]() Angiotensin I (1-9) |
|||
H-5038.0100 | Bachem | 100.0mg | EUR 756 |
![]() Mouse Angiotensin 1-7 (Ang1-7) ELISA Kit |
|||
DLR-Ang1-7-Mu-48T | DL Develop | 48T | EUR 512 |
![]() Mouse Angiotensin 1-7 (Ang1-7) ELISA Kit |
|||
DLR-Ang1-7-Mu-96T | DL Develop | 96T | EUR 667 |
![]() Mouse Angiotensin 1-7 (Ang1-7) ELISA Kit |
|||
RD-Ang1-7-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 516 |
![]() Mouse Angiotensin 1-7 (Ang1-7) ELISA Kit |
|||
RD-Ang1-7-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 716 |
![]() Mouse Angiotensin 1-7 (Ang1-7) ELISA Kit |
|||
RDR-Ang1-7-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 539 |
![]() Mouse Angiotensin 1-7 (Ang1-7) ELISA Kit |
|||
RDR-Ang1-7-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 749 |
![]() Human Brain Tissue Preparation Buffer 9: Normal Nerve Microglia |
|||
9-80021 | CHI Scientific | 1 x 100 ml | Ask for price |
![]() Human Cancer Tissue Preparation Buffer 9: Kidney Tumor Cells |
|||
9-80032 | CHI Scientific | 1 x 100 ml | Ask for price |
![]() Rat Brain Tissue Preparation Buffer 9: Normal Neuron Cells |
|||
9-80227 | CHI Scientific | 1 x 100 ml | Ask for price |
![]() Anti-NHE-9 Antibody |
|||
A05959-1 | BosterBio | 100ul | EUR 397 |
![]() Anti-ZnT-9 Antibody |
|||
A10142-1 | BosterBio | 100ul | EUR 397 |
![]() Anti-BMP-9 Antibody |
|||
A03443-1 | BosterBio | 100ul | EUR 397 |
![]() Angiotensin 1/2 (1-9) |
|||
A1007-10 | ApexBio | 10 mg | EUR 166 |
![]() Angiotensin 1/2 (1-9) |
|||
A1007-25 | ApexBio | 25 mg | EUR 212 |
![]() Angiotensin 1/2 (1-9) |
|||
A1007-5 | ApexBio | 5 mg | EUR 119 |
![]() Mouse pre-microRNA Expression Construct mir-9-2 |
|||
MMIR-9-2-PA-1 | SBI | Bacterial Streak | EUR 684 |
![]() Mouse pre-microRNA Expression Construct mir-9-3 |
|||
MMIR-9-3-PA-1 | SBI | Bacterial Streak | EUR 684 |
![]() Bovine Angiotensin (1- 9), ANG (1- 9) ELISA Kit |
|||
CELI-66004b | Lifescience Market | 96 Tests | EUR 928 |
![]() Chicken Angiotensin (1- 9), ANG (1- 9) ELISA Kit |
|||
CELI-66004c | Lifescience Market | 96 Tests | EUR 928 |
![]() Canine Angiotensin (1- 9), ANG (1- 9) ELISA Kit |
|||
CELI-66004d | Lifescience Market | 96 Tests | EUR 928 |
![]() General Angiotensin (1- 9), ANG (1- 9) ELISA Kit |
|||
CELI-66004Ge | Lifescience Market | 96 Tests | EUR 886 |
- ANG II-induced MMP-9 expression was considerably diminished by 75 and 67%, respectively, by co-incubation of the cells with a selective inhibitor of protein kinase C (GF109203X, 5 µM) or of rho kinase (Y-27632, 15 µM), however not with inhibitors of phosphoinositide 3-kinase (wortmannin, 200 nM), tyrosine kinases (genistein, 100 µM) or of reactive oxygen species (α-tocopherol, 100 µM).
TARIQUIDAR METHANESULFONATE, HYDRATE
- Thus, protein kinase C and Rho kinase are necessary parts of the inflammatory signaling pathways activated by ANG II to extend MMP-9 expression in monocytic cells. Each signaling molecules might represent potential targets for efficient management of irritation.