Angiotensin II induces NF-κB, JNK and p38 MAPK activation in monocytic cells and will increase matrix metalloproteinase-9 expression in a PKC- andRho kinase-dependent method.
- Angiotensin II (ANG II), the primary effector of the renin-angiotensin system, is implicated in endothelial permeability, recruitment and activation of the immune cells, and in addition vascular transforming by way of induction of inflammatory genes. Matrix metalloproteinases (MMPs) are thought of to be necessary inflammatory elements.
HYDROXYSTILBAMIDINE BIS(METHANESULFONATE)
- Elucidation of ANG II signaling pathways and of possible cross-talks between their parts is crucial for the event of environment friendly inhibitory medicines. The present research investigates the inflammatory signaling pathmethods activated by ANG II in cultures of human monocytic U-937 cells, and the results of particular pharmacological inhibitors of signaling intermediates on MMP-9 gene (MMP-9) expression and exercise.
- MMP-9 expression was decided by real-time PCR and supernatants had been analyzed for MMP-9 exercise by ELISA and zymography strategies. A multi-target ELISA package was employed to judge IκB, NF-κB, JNK, p38, and STAT3 activation following remedies.
- Stimulation with ANG II (100 nM) considerably elevated MMP-9 expression and exercise, and in addition activated NF-κB, JNK, and p38 by 3.8-, 2.8- and a pair of.2-fold, respectively (P < 0.01). ANG II-induced MMP-9 expression was considerably diminished by 75 and 67%, respectively, by co-incubation of the cells with a selective inhibitor of protein kinase C (GF109203X, 5 µM) or of rho kinase (Y-27632, 15 µM), however not with inhibitors of phosphoinositide 3-kinase (wortmannin, 200 nM), tyrosine kinases (genistein, 100 µM) or of reactive oxygen species (α-tocopherol, 100 µM).
Angiotensin 1-9 (Ang1-9) Monoclonal Antibody (Human), Biotinylated
- Thus, protein kinase C and Rho kinase are necessary parts of the inflammatory signaling pathways activated by ANG II to extend MMP-9 expression in monocytic cells. Each signaling molecules might represent potential targets for efficient administration of irritation.
Imatinib, Methanesulfonate Salt, >99% |
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BC040-101 | GenDepot | 1g | EUR 278.4 |
Imatinib, Methanesulfonate Salt, >99% |
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BC040-102 | GenDepot | 2g | EUR 360 |
Imatinib, Methanesulfonate Salt, >99% |
|||
BC040-105 | GenDepot | 5g | EUR 505.2 |
Imatinib, Methanesulfonate Salt, >99% |
|||
BC040-500 | GenDepot | 500mg | Ask for price |
Colistin Methanesulfonate (sodium salt) |
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C3046-1000 | ApexBio | 1 g | EUR 208.8 |
Colistin Methanesulfonate (sodium salt) |
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C3046-5000 | ApexBio | 5 g | EUR 734.4 |
Imatinib, Methanesulfonate Salt [CAS# 220127-57-1] |
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I-5508 | LC LABORATORIES | 1 g | EUR 48 |
Dabrafenib, Methanesulfonate Salt [CAS# 1195768-06-9] |
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D-5699 | LC LABORATORIES | 10 mg | EUR 44 |
Nelfinavir, Methanesulfonate Salt [CAS# 159989-65-8] |
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N-3883 | LC LABORATORIES | 10 mg | EUR 45 |
Ethyl methanesulfonate |
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20-abx186442 | Abbexa |
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Ethyl methanesulfonate |
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GX0446-100G | Glentham Life Sciences | 100 g | EUR 313.2 |
Ethyl methanesulfonate |
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GX0446-10G | Glentham Life Sciences | 10 g | EUR 88.8 |
Ethyl methanesulfonate |
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GX0446-25G | Glentham Life Sciences | 25 g | EUR 141.6 |
Ethyl methanesulfonate |
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GX0446-5G | Glentham Life Sciences | 5 g | EUR 64.8 |
Ethyl methanesulfonate |
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GX0446-10 | Glentham Life Sciences | 10 | EUR 43.5 |
Ethyl methanesulfonate |
|||
GX0446-100 | Glentham Life Sciences | 100 | EUR 229.3 |
Ethyl methanesulfonate |
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GX0446-25 | Glentham Life Sciences | 25 | EUR 87.1 |
Ethyl methanesulfonate |
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GX0446-5 | Glentham Life Sciences | 5 | EUR 23.8 |
Ethyl methanesulfonate |
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S-1930 | Scientific Laboratory Supplies | 1ML | EUR 84 |
BCX 1470 (methanesulfonate) |
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HY-50875 | MedChemExpress | 10mM/1mL | EUR 696 |
Silver methanesulfonate |
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GX5020-25G | Glentham Life Sciences | 25 g | EUR 208.8 |
Silver methanesulfonate |
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GX5020-5G | Glentham Life Sciences | 5 g | EUR 85.2 |
Silver methanesulfonate |
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GX5020-25 | Glentham Life Sciences | 25 | EUR 142.4 |
Silver methanesulfonate |
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GX5020-5 | Glentham Life Sciences | 5 | EUR 40.3 |
Pridinol Methanesulfonate |
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A8507-1000 | ApexBio | 1 g | EUR 517.2 |
Pridinol Methanesulfonate |
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A8507-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 129.6 |
Pridinol Methanesulfonate |
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A8507-50 | ApexBio | 50 mg | EUR 153.6 |
Pridinol Methanesulfonate |
|||
A8507-5000 | ApexBio | 5 g | EUR 1198.8 |
Tricaine methanesulfonate |
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GE5936-10G | Glentham Life Sciences | 10 g | EUR 68.4 |
Tricaine methanesulfonate |
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GE5936-25G | Glentham Life Sciences | 25 g | EUR 98.4 |
Tricaine methanesulfonate |
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GE5936-50G | Glentham Life Sciences | 50 g | EUR 141.6 |
Tricaine methanesulfonate |
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GE5936-5G | Glentham Life Sciences | 5 g | EUR 56.4 |
Tricaine methanesulfonate |
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GE5936-10 | Glentham Life Sciences | 10 | EUR 26.9 |
Tricaine methanesulfonate |
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GE5936-25 | Glentham Life Sciences | 25 | EUR 51.4 |
Tricaine methanesulfonate |
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GE5936-5 | Glentham Life Sciences | 5 | EUR 16.6 |
Tricaine methanesulfonate |
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GE5936-50 | Glentham Life Sciences | 50 | EUR 87.1 |
Ro 31-8220 methanesulfonate |
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1946-1 | Biovision | each | EUR 164.4 |
Ro 31-8220 methanesulfonate |
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1946-5 | Biovision | each | EUR 457.2 |
Abemaciclib (methanesulfonate) |
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HY-16297 | MedChemExpress | 500mg | EUR 542.4 |
PF-04217903 methanesulfonate |
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A3712-100 | ApexBio | 100 mg | EUR 714 |
PF-04217903 methanesulfonate |
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A3712-25 | ApexBio | 25 mg | EUR 351.6 |
PF-04217903 methanesulfonate |
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A3712-5 | ApexBio | 5 mg | EUR 157.2 |
PF-06424439 (methanesulfonate) |
|||
HY-108341A | MedChemExpress | 10mM/1mL | EUR 175.2 |
PF-04217903 (methanesulfonate) |
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HY-12017A | MedChemExpress | 10mM/1mL | EUR 187.2 |
2-Chloroethyl methanesulfonate |
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20-abx183170 | Abbexa |
|
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Colistin Sodium Methanesulfonate |
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C073-10G | TOKU-E | 10 g | EUR 984 |
Colistin Sodium Methanesulfonate |
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C073-1G | TOKU-E | 1 g | EUR 162 |
Colistin Sodium Methanesulfonate |
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C073-5G | TOKU-E | 5 g | EUR 528 |
Colistin sodium methanesulfonate |
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GA2961-1G | Glentham Life Sciences | 1 g | EUR 151.2 |
Colistin sodium methanesulfonate |
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GA2961-5G | Glentham Life Sciences | 5 g | EUR 351.6 |
Colistin sodium methanesulfonate |
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GA2961-1 | Glentham Life Sciences | 1 | EUR 95 |
Colistin sodium methanesulfonate |
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GA2961-5 | Glentham Life Sciences | 5 | EUR 261 |
Tariquidar methanesulfonate, hydrate |
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A3859-10 | ApexBio | 10 mg | EUR 226.8 |
Tariquidar methanesulfonate, hydrate |
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A3859-50 | ApexBio | 50 mg | EUR 532.8 |
Tariquidar (methanesulfonate, hydrate) |
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HY-10550A | MedChemExpress | 100mg | EUR 734.4 |
Hydroxystilbamidine bis(methanesulfonate) |
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HY-108166A | MedChemExpress | 5mg | EUR 639.6 |
Hydroxystilbamidine bis(methanesulfonate) |
|||
GW9028-10 | Glentham Life Sciences | 10 | EUR 405.4 |
Ethyl 3-Aminobenzoate (methanesulfonate) |
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C3619-100000 | ApexBio | 100 g | EUR 381.6 |
Ethyl 3-Aminobenzoate (methanesulfonate) |
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C3619-25000 | ApexBio | 25 g | EUR 153.6 |
Ethyl 3-Aminobenzoate (methanesulfonate) |
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C3619-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 135.6 |
Ethyl 3-Aminobenzoate (methanesulfonate) |
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C3619-50000 | ApexBio | 50 g | EUR 234 |
Pesticide Std Methyl Methanesulfonate Neat |
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REPET374N | Scientific Laboratory Supplies | 10MG | EUR 91.39 |
Pesticide Std Ethyl methanesulfonate Neat |
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REPET352N | Scientific Laboratory Supplies | 10MG | EUR 91.39 |
Pesticide Std Methyl Methanesulfonate 1000ug/mL in MeOH |
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REPET374 | Scientific Laboratory Supplies | 1ML | EUR 122.73 |
Pesticide Std Methyl Methanesulfonate 2000ug/mL in MeOH |
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REPET375 | Scientific Laboratory Supplies | 1ML | EUR 118.81 |
Pesticide Std Ethyl methanesulfonate 1000ug/mL in MeOH |
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REPET352 | Scientific Laboratory Supplies | 1ML | EUR 110.98 |
Pesticide Std Ethyl methanesulfonate 2000ug/mL in MeOH |
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REPET353 | Scientific Laboratory Supplies | 1ML | EUR 124.03 |
Obatoclax |
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27044 | BPS Bioscience | 5 mg | EUR 120 |
METHANESULFONIC ACID SODIUM SALT |
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713003 | Survival Technologies | each | Ask for price |
Obatoclax (Mesylate) |
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HY-10969 | MedChemExpress | 100mg | EUR 655.2 |
Obatoclax (GX15-070) |
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E1KS1057 | EnoGene | 5 mg | EUR 1333.2 |
Ethyl 3-aminobenzoate, methanesulfonic acid salt |
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20-abx184051 | Abbexa |
|
|
Angiotensin II induces NF-κB, JNK and p38 MAPK activation in monocytic cells and will increase matrix metalloproteinase-9 expression in a PKC- andRho kinase-dependent method.
- Angiotensin II (ANG II), the primary effector of the renin-angiotensin system, is implicated in endothelial permeability, recruitment and activation of the immune cells, and in addition vascular transforming by way of induction of inflammatory genes. Matrix metalloproteinases (MMPs) are thought of to be necessary inflammatory elements.
Mouse pre-microRNA Expression Assemble mir-9-1
- Elucidation of ANG II signaling pathways and of potential cross-talks between their components is crucial for the event of environment friendly inhibitory medicines.
- The present research investigates the inflammatory signaling pathways activated by ANG II in cultures of human monocytic U-937 cells, and the results of particular pharmacological inhibitors of signaling intermediates on MMP-9 gene (MMP-9) expression and exercise. MMP-9 expression was decided by real-time PCR and supernatants had been analyzed for MMP-9 exercise by ELISA and zymography strategies.
- A multi-target ELISA package was employed to judge IκB, NF-κB, JNK, p38, and STAT3 activation following remedies. Stimulation with ANG II (100 nM) considerably elevated MMP-9 expression and exercise, and in addition activated NF-κB, JNK, and p38 by 3.8-, 2.8- and a pair of.2-fold, respectively (P < 0.01).
Angiotensin 1-9 (Ang1-9) Monoclonal Antibody |
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CAU29565-100ul | Biomatik Corporation | 100ul | EUR 262.1 |
Angiotensin 1-9 (Ang1-9) Monoclonal Antibody |
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CAU29565-200ul | Biomatik Corporation | 200ul | EUR 327.6 |
Angiotensin 1-9 (Ang1-9) Monoclonal Antibody (Human) |
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4-MAT844Hu21 | Cloud-Clone |
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Angiotensin 1-9 (Ang1-9) Monoclonal Antibody (Human), PE |
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4-MAT844Hu21-PE | Cloud-Clone |
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Angiotensin 1-9 (Ang1-9) Monoclonal Antibody (Human), APC |
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4-MAT844Hu21-APC | Cloud-Clone |
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Angiotensin 1-9 (Ang1-9) Monoclonal Antibody (Human), Cy3 |
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4-MAT844Hu21-Cy3 | Cloud-Clone |
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Angiotensin 1-9 (Ang1-9) Monoclonal Antibody (Human), HRP |
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4-MAT844Hu21-HRP | Cloud-Clone |
|
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Angiotensin 1-9 (Ang1-9) Monoclonal Antibody (Human), FITC |
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4-MAT844Hu21-FITC | Cloud-Clone |
|
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Angiotensin 1-9 (Ang1-9) Monoclonal Antibody (Human), Biotinylated |
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4-MAT844Hu21-Biotin | Cloud-Clone |
|
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Angiotensin 1-9 (Ang1-9) Monoclonal Antibody (Human), APC-Cy7 |
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4-MAT844Hu21-APC-Cy7 | Cloud-Clone |
|
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Angiotensin 1-7 (Ang1-7) Monoclonal Antibody |
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CAU29564-100ul | Biomatik Corporation | 100ul | EUR 294.7 |
Angiotensin 1-7 (Ang1-7) Monoclonal Antibody |
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CAU29564-200ul | Biomatik Corporation | 200ul | EUR 367.9 |
Angiotensin 1-7 (Ang1-7) Monoclonal Antibody |
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CAU30504-100ul | Biomatik Corporation | 100ul | EUR 301.4 |
Angiotensin 1-7 (Ang1-7) Monoclonal Antibody |
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CAU30504-200ul | Biomatik Corporation | 200ul | EUR 376.3 |
Angiotensin 1-7 (Ang1-7) Monoclonal Antibody |
|||
CAU29480-100ul | Biomatik Corporation | 100ul | EUR 294.7 |
Angiotensin 1-7 (Ang1-7) Monoclonal Antibody |
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CAU29480-200ul | Biomatik Corporation | 200ul | EUR 367.9 |
Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Human, Mouse, Rat) |
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4-MAS085Mi21 | Cloud-Clone |
|
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Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Rat) |
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4-MAS085Ra21 | Cloud-Clone |
|
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Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Human, Mouse, Rat), PE |
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4-MAS085Mi21-PE | Cloud-Clone |
|
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Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Human, Mouse, Rat), APC |
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4-MAS085Mi21-APC | Cloud-Clone |
|
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Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Human, Mouse, Rat), Cy3 |
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4-MAS085Mi21-Cy3 | Cloud-Clone |
|
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Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Human, Mouse, Rat), HRP |
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4-MAS085Mi21-HRP | Cloud-Clone |
|
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Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Human, Mouse, Rat), FITC |
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4-MAS085Mi21-FITC | Cloud-Clone |
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Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Rat), PE |
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4-MAS085Ra21-PE | Cloud-Clone |
|
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Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Rat), APC |
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4-MAS085Ra21-APC | Cloud-Clone |
|
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Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Rat), Cy3 |
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4-MAS085Ra21-Cy3 | Cloud-Clone |
|
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Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Rat), HRP |
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4-MAS085Ra21-HRP | Cloud-Clone |
|
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Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Rat), FITC |
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4-MAS085Ra21-FITC | Cloud-Clone |
|
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Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Human, Mouse, Rat), APC-Cy7 |
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4-MAS085Mi21-APC-Cy7 | Cloud-Clone |
|
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Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Human, Mouse, Rat), Biotinylated |
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4-MAS085Mi21-Biotin | Cloud-Clone |
|
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Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Pan-species) |
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4-MAS085Ge22 | Cloud-Clone |
|
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Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Rat), APC-Cy7 |
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4-MAS085Ra21-APC-Cy7 | Cloud-Clone |
|
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Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Rat), Biotinylated |
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4-MAS085Ra21-Biotin | Cloud-Clone |
|
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Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Pan-species), PE |
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4-MAS085Ge22-PE | Cloud-Clone |
|
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Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Pan-species), APC |
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4-MAS085Ge22-APC | Cloud-Clone |
|
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Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Pan-species), Cy3 |
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4-MAS085Ge22-Cy3 | Cloud-Clone |
|
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Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Pan-species), HRP |
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4-MAS085Ge22-HRP | Cloud-Clone |
|
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Angiotensin 1-9 (Ang1-9) Antibody |
|||
20-abx132109 | Abbexa |
|
|
Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Pan-species), FITC |
|||
4-MAS085Ge22-FITC | Cloud-Clone |
|
|
Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Pan-species), APC-Cy7 |
|||
4-MAS085Ge22-APC-Cy7 | Cloud-Clone |
|
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Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Pan-species), Biotinylated |
|||
4-MAS085Ge22-Biotin | Cloud-Clone |
|
|
Angiotensin II (AngII) Monoclonal Antibody |
|||
CAU30568-100ul | Biomatik Corporation | 100ul | EUR 241.9 |
Angiotensin II (AngII) Monoclonal Antibody |
|||
CAU30568-200ul | Biomatik Corporation | 200ul | EUR 302.4 |
Mouse Angiotensin 1-9 (Ang1-9) ELISA Kit |
|||
abx353312-96tests | Abbexa | 96 tests | EUR 943.2 |
Rat Angiotensin 1-9(Ang1-9) |
|||
QY-E11784 | Qayee Biotechnology | 96T | EUR 448.8 |
Angiotensin 1-9 (Ang1-9) CLIA Kit |
|||
20-abx490554 | Abbexa |
|
|
Angiotensin 1-9 (Ang1-9) ELISA Kit |
|||
20-abx258341 | Abbexa |
|
|
Monoclonal Angiotensin Converting Enzyme 1 Antibody |
|||
APG01871G | Leading Biology | 0.1ml | EUR 580.8 |
Human/Mouse/Rat Angiotensin 1-9 (Ang1-9) ELISA Kit |
|||
EKU08764-48T | Biomatik Corporation | 48T | EUR 616.91 |
Human/Mouse/Rat Angiotensin 1-9 (Ang1-9) ELISA Kit |
|||
EKU08764-5x96T | Biomatik Corporation | 5x96T | EUR 4186.18 |
Human/Mouse/Rat Angiotensin 1-9 (Ang1-9) ELISA Kit |
|||
EKU08764-96T | Biomatik Corporation | 96T | EUR 881.3 |
Human/Mouse/Rat Angiotensin 1-9 (Ang1-9) ELISA Kit |
|||
EKN49875-48T | Biomatik Corporation | 48T | EUR 383.81 |
Human/Mouse/Rat Angiotensin 1-9 (Ang1-9) ELISA Kit |
|||
EKN49875-5x96T | Biomatik Corporation | 5x96T | EUR 2604.43 |
Human/Mouse/Rat Angiotensin 1-9 (Ang1-9) ELISA Kit |
|||
EKN49875-96T | Biomatik Corporation | 96T | EUR 548.3 |
ELISA kit for Mouse Ang1-9 (Angiotensin 1-9) Kit |
|||
E-EL-M2682 | Elabscience Biotech | 1 plate of 96 wells | EUR 640.8 |
Rat Angiotensin 1-9 (Ang1-9) ELISA Kit |
|||
abx257809-96tests | Abbexa | 96 tests | EUR 895.2 |
Human Angiotensin 1-9 (Ang1-9) CLIA Kit |
|||
20-abx490553 | Abbexa |
|
|
Human Angiotensin 1-9 (Ang1-9) ELISA Kit |
|||
20-abx150652 | Abbexa |
|
|
Human Angiotensin 1-9 (Ang1-9)ELISA Kit |
|||
201-12-2829 | SunredBio | 96 tests | EUR 528 |
Human Angiotensin 1-9 (Ang1-9) ELISA Kit |
|||
CET844Hu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 5991.96 |
Human Angiotensin 1-9 (Ang1-9) ELISA Kit |
|||
CET844Hu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 598.63 |
Human Angiotensin 1-9 (Ang1-9) ELISA Kit |
|||
CET844Hu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 803.76 |
Human Angiotensin 1-9 (Ang1-9) ELISA Kit |
|||
CET844Hu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 3256.92 |
Human Angiotensin 1-9 (Ang1-9) ELISA Kit |
|||
4-CET844Hu | Cloud-Clone |
|
|
Human Angiotensin 1-9 (Ang1-9) ELISA Kit |
|||
abx575059-96tests | Abbexa | 96 tests | EUR 801.6 |
Human Angiotensin 1-9 (Ang1-9) ELISA Kit |
|||
DLR-Ang1-9-Hu-48T | DL Develop | 48T | EUR 601.2 |
Human Angiotensin 1-9 (Ang1-9) ELISA Kit |
|||
DLR-Ang1-9-Hu-96T | DL Develop | 96T | EUR 781.2 |
Human Angiotensin 1-9 (Ang1-9) ELISA Kit |
|||
RD-Ang1-9-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 603.6 |
Human Angiotensin 1-9 (Ang1-9) ELISA Kit |
|||
RD-Ang1-9-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 836.4 |
Human Angiotensin 1-9 (Ang1-9) ELISA Kit |
|||
RDR-Ang1-9-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 630 |
Human Angiotensin 1-9 (Ang1-9) ELISA Kit |
|||
RDR-Ang1-9-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 874.8 |
Human Angiotensin 1-9(Ang1-9)ELISA Kit |
|||
QY-E00730 | Qayee Biotechnology | 96T | EUR 433.2 |
Human Angiotensin 1-9 (Ang1-9) ELISA Kit |
|||
RDR-Ang1-9-Hu-48T | Reddot Biotech | 48T | EUR 456.96 |
- ANG II-induced MMP-9 expression was considerably diminished by 75 and 67%, respectively, by co-incubation of the cells with a selective inhibitor of protein kinase C (GF109203X, 5 µM) or of rho kinase (Y-27632, 15 µM), however not with inhibitors of phosphoinositide 3-kinase (wortmannin, 200 nM), tyrosine kinases (genistein, 100 µM) or of reactive oxygen species (α-tocopherol, 100 µM).
TARIQUIDAR METHANESULFONATE, HYDRATE
- Thus, protein kinase C and Rho kinase are necessary parts of the inflammatory signaling pathways activated by ANG II to extend MMP-9 expression in monocytic cells. Each signaling molecules might represent potential targets for efficient management of irritation.