Angiotensin II induces NF-κB, JNK and p38 MAPK activation in monocytic cells and will increase matrix metalloproteinase-9 expression in a PKC- andRho kinase-dependent method.
- Angiotensin II (ANG II), the primary effector of the renin-angiotensin system, is implicated in endothelial permeability, recruitment and activation of the immune cells, and in addition vascular transforming by way of induction of inflammatory genes. Matrix metalloproteinases (MMPs) are thought of to be necessary inflammatory elements.
HYDROXYSTILBAMIDINE BIS(METHANESULFONATE)
- Elucidation of ANG II signaling pathways and of possible cross-talks between their parts is crucial for the event of environment friendly inhibitory medicines. The present research investigates the inflammatory signaling pathmethods activated by ANG II in cultures of human monocytic U-937 cells, and the results of particular pharmacological inhibitors of signaling intermediates on MMP-9 gene (MMP-9) expression and exercise.
- MMP-9 expression was decided by real-time PCR and supernatants had been analyzed for MMP-9 exercise by ELISA and zymography strategies. A multi-target ELISA package was employed to judge IκB, NF-κB, JNK, p38, and STAT3 activation following remedies.
- Stimulation with ANG II (100 nM) considerably elevated MMP-9 expression and exercise, and in addition activated NF-κB, JNK, and p38 by 3.8-, 2.8- and a pair of.2-fold, respectively (P < 0.01). ANG II-induced MMP-9 expression was considerably diminished by 75 and 67%, respectively, by co-incubation of the cells with a selective inhibitor of protein kinase C (GF109203X, 5 µM) or of rho kinase (Y-27632, 15 µM), however not with inhibitors of phosphoinositide 3-kinase (wortmannin, 200 nM), tyrosine kinases (genistein, 100 µM) or of reactive oxygen species (α-tocopherol, 100 µM).
Angiotensin 1-9 (Ang1-9) Monoclonal Antibody (Human), Biotinylated
- Thus, protein kinase C and Rho kinase are necessary parts of the inflammatory signaling pathways activated by ANG II to extend MMP-9 expression in monocytic cells. Each signaling molecules might represent potential targets for efficient administration of irritation.
Metaphit Methanesulfonate Salt |
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| M258810 | Toronto Research Chemicals | 250mg | EUR 213 |
Phenamil Methanesulfonate Salt |
|||
| P294780 | Toronto Research Chemicals | 10mg | EUR 58 |
Pridinol Methanesulfonate Salt |
|||
| P715000 | Toronto Research Chemicals | 100mg | EUR 679 |
Phentolamine Methanesulfonate Salt |
|||
| P302560 | Toronto Research Chemicals | 100mg | EUR 86 |
BAY 57-1293 Methanesulfonate Salt |
|||
| B118805 | Toronto Research Chemicals | 5mg | EUR 82 |
Imatinib, Methanesulfonate Salt, >99% |
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| BC040-101 | GenDepot | 1g | EUR 142 |
Imatinib, Methanesulfonate Salt, >99% |
|||
| BC040-102 | GenDepot | 2g | EUR 205 |
Imatinib, Methanesulfonate Salt, >99% |
|||
| BC040-105 | GenDepot | 5g | EUR 302 |
Imatinib, Methanesulfonate Salt, >99% |
|||
| BC040-500 | GenDepot | 500mg | Ask for price |
Metaphit Methanesulfonate Salt (1-(1-[3-Isothiocyanato]phenyl)cyclohexylpiperidine, Methanesulfonate Salt) |
|||
| MBS6089256-25mg | MyBiosource | 2.5(mg | EUR 575 |
Metaphit Methanesulfonate Salt (1-(1-[3-Isothiocyanato]phenyl)cyclohexylpiperidine, Methanesulfonate Salt) |
|||
| MBS6089256-5x25mg | MyBiosource | 5x2.5mg | EUR 2440 |
BAY 57-1293 Methanesulfonate Salt-d4 |
|||
| B540591 | Toronto Research Chemicals | 50mg | EUR 9200 |
Pridinol Methanesulfonate Salt (a,a-Diphenyl-1-piperidinepropanol Methanesulfonate) |
|||
| MBS6048097-100mg | MyBiosource | 100(mg | EUR 505 |
Pridinol Methanesulfonate Salt (a,a-Diphenyl-1-piperidinepropanol Methanesulfonate) |
|||
| MBS6048097-5x100mg | MyBiosource | 5x100mg | EUR 2125 |
Colistin Methanesulfonate (sodium salt) |
|||
| C3046-1000 | ApexBio | 1 g | EUR 121.6 |
Colistin Methanesulfonate (sodium salt) |
|||
| C3046-5000 | ApexBio | 5 g | EUR 547.2 |
Colistin methanesulfonate (sodium salt) |
|||
| HY-A0214 | MedChemExpress | 100 mg | EUR 54.11 |
Colistin Methanesulfonate (sodium salt) |
|||
| MBS5756763-100mg | MyBiosource | 100mg | EUR 160 |
Colistin Methanesulfonate (sodium salt) |
|||
| MBS5756763-200mg | MyBiosource | 200mg | EUR 190 |
Colistin Methanesulfonate (sodium salt) |
|||
| MBS5756763-500mg | MyBiosource | 500mg | EUR 270 |
Colistin Methanesulfonate (sodium salt) |
|||
| MBS5756763-50mg | MyBiosource | 50mg | EUR 145 |
Colistin Methanesulfonate (sodium salt) |
|||
| MBS5756763-5mg | MyBiosource | 5mg | EUR 125 |
Colistin methanesulfonate sodium salt |
|||
| T21518-10mg | TargetMol Chemicals | 10mg | Ask for price |
Colistin methanesulfonate sodium salt |
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| T21518-1g | TargetMol Chemicals | 1g | Ask for price |
Colistin methanesulfonate sodium salt |
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| T21518-1mg | TargetMol Chemicals | 1mg | Ask for price |
Colistin methanesulfonate sodium salt |
|||
| T21518-50mg | TargetMol Chemicals | 50mg | Ask for price |
Colistin methanesulfonate sodium salt |
|||
| T21518-5mg | TargetMol Chemicals | 5mg | Ask for price |
Imatinib, Methanesulfonate Salt [CAS# 220127-57-1] |
|||
| I-5508 | LC LABORATORIES | 1 g | EUR 48 |
Dabrafenib, Methanesulfonate Salt [CAS# 1195768-06-9] |
|||
| D-5699 | LC LABORATORIES | 10 mg | EUR 44 |
Nelfinavir, Methanesulfonate Salt [CAS# 159989-65-8] |
|||
| N-3883 | LC LABORATORIES | 10 mg | EUR 45 |
Phentolamine, Methanesulfonate Salt (2-[N-(m-Hydroxyphenyl)-p-toluidinomethyl]imidazoline, Methanesulfonate) |
|||
| MBS6048058-250mg | MyBiosource | 250(mg | EUR 500 |
Phentolamine, Methanesulfonate Salt (2-[N-(m-Hydroxyphenyl)-p-toluidinomethyl]imidazoline, Methanesulfonate) |
|||
| MBS6048058-5x250mg | MyBiosource | 5x250mg | EUR 2090 |
3,4-Dihydro-2H,10H-azepino[3,4-b]indole-1,5-dione Methanesulfonate Salt |
|||
| MBS6046336-5mg | MyBiosource | 5(mg | EUR 525 |
3,4-Dihydro-2H,10H-azepino[3,4-b]indole-1,5-dione Methanesulfonate Salt |
|||
| MBS6046336-5x5mg | MyBiosource | 5x5(mg | EUR 2210 |
Ethyl Methanesulfonate |
|||
| 15519-54 | NACALAI TESQUE | 5G | EUR 42.7 |
Butyl Methanesulfonate |
|||
| B694095 | Toronto Research Chemicals | 1g | EUR 230 |
Ethyl methanesulfonate |
|||
| 20-abx186442 | Abbexa |
|
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Hexyl Methanesulfonate |
|||
| H297155 | Toronto Research Chemicals | 1g | EUR 187 |
Ethyl methanesulfonate |
|||
| GX0446 | Glentham Life Sciences | 5g | EUR 209.98 |
Ethyl methanesulfonate |
|||
| GX0446-10 | Glentham Life Sciences | 10 | EUR 43.5 |
Ethyl methanesulfonate |
|||
| GX0446-100 | Glentham Life Sciences | 100 | EUR 229.3 |
Ethyl methanesulfonate |
|||
| GX0446-100G | Glentham Life Sciences | 100 g | EUR 313.2 |
Ethyl methanesulfonate |
|||
| GX0446-10G | Glentham Life Sciences | 10 g | EUR 88.8 |
Ethyl methanesulfonate |
|||
| GX0446-25 | Glentham Life Sciences | 25 | EUR 87.1 |
Ethyl methanesulfonate |
|||
| GX0446-25G | Glentham Life Sciences | 25 g | EUR 141.6 |
Ethyl methanesulfonate |
|||
| GX0446-5 | Glentham Life Sciences | 5 | EUR 23.8 |
Ethyl methanesulfonate |
|||
| GX0446-5G | Glentham Life Sciences | 5 g | EUR 64.8 |
Ethyl Methanesulfonate |
|||
| E917995 | Toronto Research Chemicals | 100g | EUR 126 |
CYH33 (methanesulfonate) |
|||
| HY-123938A | MedChemExpress | 10 mg | EUR 5140.77 |
CYH33 methanesulfonate |
|||
| MBS5799537-10mg | MyBiosource | 10mg | EUR 1395 |
CYH33 methanesulfonate |
|||
| MBS5799537-5mg | MyBiosource | 5(mg | EUR 925 |
CYH33 methanesulfonate |
|||
| MBS5799537-5x10mg | MyBiosource | 5x10(mg | EUR 6120 |
CYH33 methanesulfonate |
|||
| T38979-10mg | TargetMol Chemicals | 10mg | Ask for price |
CYH33 methanesulfonate |
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| T38979-1g | TargetMol Chemicals | 1g | Ask for price |
CYH33 methanesulfonate |
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| T38979-1mg | TargetMol Chemicals | 1mg | Ask for price |
CYH33 methanesulfonate |
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| T38979-50mg | TargetMol Chemicals | 50mg | Ask for price |
CYH33 methanesulfonate |
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| T38979-5mg | TargetMol Chemicals | 5mg | Ask for price |
Methyl Methanesulfonate |
|||
| 22801-14 | NACALAI TESQUE | 10G | EUR 44.8 |
Methyl Methanesulfonate |
|||
| M320170 | Toronto Research Chemicals | 10g | EUR 86 |
Methyl methanesulfonate |
|||
| MBS5786682-10mg | MyBiosource | 10mg | EUR 160 |
Methyl methanesulfonate |
|||
| MBS5786682-25mg | MyBiosource | 25mg | EUR 200 |
Methyl methanesulfonate |
|||
| MBS5786682-50mg | MyBiosource | 50(mg | EUR 250 |
Methyl methanesulfonate |
|||
| MBS5786682-5mg | MyBiosource | 5(mg | EUR 145 |
Methyl methanesulfonate |
|||
| T9985-10mg | TargetMol Chemicals | 10mg | Ask for price |
Methyl methanesulfonate |
|||
| T9985-1g | TargetMol Chemicals | 1g | Ask for price |
Methyl methanesulfonate |
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| T9985-1mg | TargetMol Chemicals | 1mg | Ask for price |
Methyl methanesulfonate |
|||
| T9985-50mg | TargetMol Chemicals | 50mg | Ask for price |
Methyl methanesulfonate |
|||
| T9985-5mg | TargetMol Chemicals | 5mg | Ask for price |
Acetyl Methanesulfonate |
|||
| A173895 | Toronto Research Chemicals | 10g | EUR 489 |
Propyl Methanesulfonate |
|||
| B523550 | Toronto Research Chemicals | 100mg | EUR 63 |
Silver methanesulfonate |
|||
| GX5020 | Glentham Life Sciences | 5g | EUR 130.36 |
Silver methanesulfonate |
|||
| GX5020-25 | Glentham Life Sciences | 25 | EUR 142.4 |
Angiotensin II induces NF-κB, JNK and p38 MAPK activation in monocytic cells and will increase matrix metalloproteinase-9 expression in a PKC- andRho kinase-dependent method.
- Angiotensin II (ANG II), the primary effector of the renin-angiotensin system, is implicated in endothelial permeability, recruitment and activation of the immune cells, and in addition vascular transforming by way of induction of inflammatory genes. Matrix metalloproteinases (MMPs) are thought of to be necessary inflammatory elements.
Mouse pre-microRNA Expression Assemble mir-9-1
- Elucidation of ANG II signaling pathways and of potential cross-talks between their components is crucial for the event of environment friendly inhibitory medicines.
- The present research investigates the inflammatory signaling pathways activated by ANG II in cultures of human monocytic U-937 cells, and the results of particular pharmacological inhibitors of signaling intermediates on MMP-9 gene (MMP-9) expression and exercise. MMP-9 expression was decided by real-time PCR and supernatants had been analyzed for MMP-9 exercise by ELISA and zymography strategies.
- A multi-target ELISA package was employed to judge IκB, NF-κB, JNK, p38, and STAT3 activation following remedies. Stimulation with ANG II (100 nM) considerably elevated MMP-9 expression and exercise, and in addition activated NF-κB, JNK, and p38 by 3.8-, 2.8- and a pair of.2-fold, respectively (P < 0.01).
Angiotensin 1-9 (Ang1-9) Monoclonal Antibody |
|||
| CAU29565-100ul | Biomatik Corporation | 100ul | EUR 262.1 |
Angiotensin 1-9 (Ang1-9) Monoclonal Antibody |
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| CAU29565-200ul | Biomatik Corporation | 200ul | EUR 327.6 |
Monoclonal Antibody to Angiotensin 1-9 (Ang1-9) |
|||
| MAT844Hu21 | Cloud-Clone | 100ul | EUR 273 |
Monoclonal Antibody to Angiotensin 1-9 (Ang1-9) |
|||
| MBS2085959-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Angiotensin 1-9 (Ang1-9) Monoclonal Antibody (Human) |
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| 4-MAT844Hu21 | Cloud-Clone |
|
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Angiotensin 1-9 (Ang1-9) Monoclonal Antibody (Human), PE |
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| 4-MAT844Hu21-PE | Cloud-Clone |
|
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Angiotensin 1-9 (Ang1-9) Monoclonal Antibody (Human), APC |
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| 4-MAT844Hu21-APC | Cloud-Clone |
|
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Angiotensin 1-9 (Ang1-9) Monoclonal Antibody (Human), Cy3 |
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| 4-MAT844Hu21-Cy3 | Cloud-Clone |
|
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Angiotensin 1-9 (Ang1-9) Monoclonal Antibody (Human), HRP |
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| 4-MAT844Hu21-HRP | Cloud-Clone |
|
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Angiotensin 1-9 (Ang1-9) Monoclonal Antibody (Human), FITC |
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| 4-MAT844Hu21-FITC | Cloud-Clone |
|
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Angiotensin 1-9 (Ang1-9) Monoclonal Antibody (Human), Biotinylated |
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| 4-MAT844Hu21-Biotin | Cloud-Clone |
|
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PE-Linked Monoclonal Antibody to Angiotensin 1-9 (Ang1-9) |
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| MBS2085623-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Angiotensin 1-9 (Ang1-9) Monoclonal Antibody (Human), APC-Cy7 |
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| 4-MAT844Hu21-APC-Cy7 | Cloud-Clone |
|
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APC-Linked Monoclonal Antibody to Angiotensin 1-9 (Ang1-9) |
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| MBS2085624-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Cy3-Linked Monoclonal Antibody to Angiotensin 1-9 (Ang1-9) |
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| MBS2085625-INQUIRE | MyBiosource | INQUIRE | Ask for price |
HRP-Linked Monoclonal Antibody to Angiotensin 1-9 (Ang1-9) |
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| MBS2085627-INQUIRE | MyBiosource | INQUIRE | Ask for price |
FITC-Linked Monoclonal Antibody to Angiotensin 1-9 (Ang1-9) |
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| MBS2085626-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Biotin-Linked Monoclonal Antibody to Angiotensin 1-9 (Ang1-9) |
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| MBS2091271-INQUIRE | MyBiosource | INQUIRE | Ask for price |
APC/CY7-Linked Monoclonal Antibody to Angiotensin 1-9 (Ang1-9) |
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| MBS2085622-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Human, Mouse, Rat) |
|||
| 4-MAS085Mi21 | Cloud-Clone |
|
|
Angiotensin 1-7 (Ang1-7) Monoclonal Antibody |
|||
| CAU29480-100ul | Biomatik Corporation | 100ul | EUR 294.7 |
Angiotensin 1-7 (Ang1-7) Monoclonal Antibody |
|||
| CAU29480-200ul | Biomatik Corporation | 200ul | EUR 367.9 |
Angiotensin 1-7 (Ang1-7) Monoclonal Antibody |
|||
| CAU29564-100ul | Biomatik Corporation | 100ul | EUR 294.7 |
Angiotensin 1-7 (Ang1-7) Monoclonal Antibody |
|||
| CAU29564-200ul | Biomatik Corporation | 200ul | EUR 367.9 |
Angiotensin 1-7 (Ang1-7) Monoclonal Antibody |
|||
| CAU30504-100ul | Biomatik Corporation | 100ul | EUR 301.4 |
Angiotensin 1-7 (Ang1-7) Monoclonal Antibody |
|||
| CAU30504-200ul | Biomatik Corporation | 200ul | EUR 376.3 |
Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Human, Mouse, Rat), PE |
|||
| 4-MAS085Mi21-PE | Cloud-Clone |
|
|
Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Human, Mouse, Rat), APC |
|||
| 4-MAS085Mi21-APC | Cloud-Clone |
|
|
Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Human, Mouse, Rat), Cy3 |
|||
| 4-MAS085Mi21-Cy3 | Cloud-Clone |
|
|
Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Human, Mouse, Rat), HRP |
|||
| 4-MAS085Mi21-HRP | Cloud-Clone |
|
|
Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Human, Mouse, Rat), FITC |
|||
| 4-MAS085Mi21-FITC | Cloud-Clone |
|
|
Monoclonal Antibody to Angiotensin 1-7 (Ang1-7) |
|||
| MAS085Ge21 | Cloud-Clone | 100ul | EUR 324 |
Monoclonal Antibody to Angiotensin 1-7 (Ang1-7) |
|||
| MAS085Ge22 | Cloud-Clone | 100ul | EUR 314 |
Monoclonal Antibody to Angiotensin 1-7 (Ang1-7) |
|||
| MAS085Mi21 | Cloud-Clone | 100ul | EUR 307 |
Monoclonal Antibody to Angiotensin 1-7 (Ang1-7) |
|||
| MAS085Mi22 | Cloud-Clone | 100ul | EUR 317 |
Monoclonal Antibody to Angiotensin 1-7 (Ang1-7) |
|||
| MAS085Ra21 | Cloud-Clone | 100ul | EUR 307 |
Monoclonal Antibody to Angiotensin 1-7 (Ang1-7) |
|||
| MBS2111335-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Monoclonal Antibody to Angiotensin 1-7 (Ang1-7) |
|||
| MBS2025733-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Monoclonal Antibody to Angiotensin 1-7 (Ang1-7) |
|||
| MBS2085958-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Rat) |
|||
| 4-MAS085Ra21 | Cloud-Clone |
|
|
Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Human, Mouse, Rat), APC-Cy7 |
|||
| 4-MAS085Mi21-APC-Cy7 | Cloud-Clone |
|
|
Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Human, Mouse, Rat), Biotinylated |
|||
| 4-MAS085Mi21-Biotin | Cloud-Clone |
|
|
Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Rat), PE |
|||
| 4-MAS085Ra21-PE | Cloud-Clone |
|
|
Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Rat), APC |
|||
| 4-MAS085Ra21-APC | Cloud-Clone |
|
|
Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Rat), Cy3 |
|||
| 4-MAS085Ra21-Cy3 | Cloud-Clone |
|
|
Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Rat), HRP |
|||
| 4-MAS085Ra21-HRP | Cloud-Clone |
|
|
Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Rat), FITC |
|||
| 4-MAS085Ra21-FITC | Cloud-Clone |
|
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Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Pan-species) |
|||
| 4-MAS085Ge22 | Cloud-Clone |
|
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Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Rat), APC-Cy7 |
|||
| 4-MAS085Ra21-APC-Cy7 | Cloud-Clone |
|
|
Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Rat), Biotinylated |
|||
| 4-MAS085Ra21-Biotin | Cloud-Clone |
|
|
PE-Linked Monoclonal Antibody to Angiotensin 1-7 (Ang1-7) |
|||
| MBS2085300-INQUIRE | MyBiosource | INQUIRE | Ask for price |
PE-Linked Monoclonal Antibody to Angiotensin 1-7 (Ang1-7) |
|||
| MBS2085308-INQUIRE | MyBiosource | INQUIRE | Ask for price |
PE-Linked Monoclonal Antibody to Angiotensin 1-7 (Ang1-7) |
|||
| MBS2085318-INQUIRE | MyBiosource | INQUIRE | Ask for price |
APC-Linked Monoclonal Antibody to Angiotensin 1-7 (Ang1-7) |
|||
| MBS2085301-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Cy3-Linked Monoclonal Antibody to Angiotensin 1-7 (Ang1-7) |
|||
| MBS2085302-INQUIRE | MyBiosource | INQUIRE | Ask for price |
HRP-Linked Monoclonal Antibody to Angiotensin 1-7 (Ang1-7) |
|||
| MBS2085304-INQUIRE | MyBiosource | INQUIRE | Ask for price |
APC-Linked Monoclonal Antibody to Angiotensin 1-7 (Ang1-7) |
|||
| MBS2085310-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Cy3-Linked Monoclonal Antibody to Angiotensin 1-7 (Ang1-7) |
|||
| MBS2085312-INQUIRE | MyBiosource | INQUIRE | Ask for price |
HRP-Linked Monoclonal Antibody to Angiotensin 1-7 (Ang1-7) |
|||
| MBS2085315-INQUIRE | MyBiosource | INQUIRE | Ask for price |
APC-Linked Monoclonal Antibody to Angiotensin 1-7 (Ang1-7) |
|||
| MBS2085319-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Cy3-Linked Monoclonal Antibody to Angiotensin 1-7 (Ang1-7) |
|||
| MBS2085320-INQUIRE | MyBiosource | INQUIRE | Ask for price |
HRP-Linked Monoclonal Antibody to Angiotensin 1-7 (Ang1-7) |
|||
| MBS2085322-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Pan-species), PE |
|||
| 4-MAS085Ge22-PE | Cloud-Clone |
|
|
FITC-Linked Monoclonal Antibody to Angiotensin 1-7 (Ang1-7) |
|||
| MBS2085303-INQUIRE | MyBiosource | INQUIRE | Ask for price |
FITC-Linked Monoclonal Antibody to Angiotensin 1-7 (Ang1-7) |
|||
| MBS2085313-INQUIRE | MyBiosource | INQUIRE | Ask for price |
FITC-Linked Monoclonal Antibody to Angiotensin 1-7 (Ang1-7) |
|||
| MBS2085321-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Pan-species), APC |
|||
| 4-MAS085Ge22-APC | Cloud-Clone |
|
|
Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Pan-species), Cy3 |
|||
| 4-MAS085Ge22-Cy3 | Cloud-Clone |
|
|
Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Pan-species), HRP |
|||
| 4-MAS085Ge22-HRP | Cloud-Clone |
|
|
Angiotensin 1-7 (Ang1-7) Monoclonal Antibody (Pan-species), FITC |
|||
| 4-MAS085Ge22-FITC | Cloud-Clone |
|
|
Biotin-Linked Monoclonal Antibody to Angiotensin 1-7 (Ang1-7) |
|||
| MBS2091266-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Biotin-Linked Monoclonal Antibody to Angiotensin 1-7 (Ang1-7) |
|||
| MBS2091267-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Biotin-Linked Monoclonal Antibody to Angiotensin 1-7 (Ang1-7) |
|||
| MBS2091268-INQUIRE | MyBiosource | INQUIRE | Ask for price |
- ANG II-induced MMP-9 expression was considerably diminished by 75 and 67%, respectively, by co-incubation of the cells with a selective inhibitor of protein kinase C (GF109203X, 5 µM) or of rho kinase (Y-27632, 15 µM), however not with inhibitors of phosphoinositide 3-kinase (wortmannin, 200 nM), tyrosine kinases (genistein, 100 µM) or of reactive oxygen species (α-tocopherol, 100 µM).
TARIQUIDAR METHANESULFONATE, HYDRATE
- Thus, protein kinase C and Rho kinase are necessary parts of the inflammatory signaling pathways activated by ANG II to extend MMP-9 expression in monocytic cells. Each signaling molecules might represent potential targets for efficient management of irritation.
