Multi–panel immunofluorescence evaluation of tumor infiltrating lymphocytes in triple adverse breast most cancers: Evolution of tumor immune profiles and affected person prognosis.
- The evolutionary adjustments in immune profiles of triple adverse breast most cancers (TNBC) aren’t properly understood, though it’s identified that immune checkpoint inhibitors have diminished exercise in closely pre-treated TNBC sufferers. This examine was designed to characterize immune profile adjustments of longitudinal tumor specimens by learning immune subsets of tumor infiltrating lymphocytes (TILs) in paired main and metastatic TNBC in a cohort of “poor end result” (relapsed inside 5 years) sufferers.
- Immune profiles of TNBCs in a cohort of “good end result” (no relapse inside 5 years) sufferers have been additionally analyzed. Immune subsets have been characterised for CD4, CD8, FOXP3, CD20, CD33, and PD1 utilizing immuno-fluorescence staining in stroma, tumor, and mixed stroma and tumor tissue. TIL subsets in “good end result” versus “poor end result” sufferers have been additionally analyzed. In contrast with main, metastatic TNBCs had considerably decrease TILs by hematoxylin and eosin (H&E) staining.
HAV HAV P2C recombinant antigen
- Stromal TILs (sTILs), however not tumoral TILs (tTILs) had considerably lowered cytotoxic CD8+ T cells (CTLs), PD1+ CTLs, and whole PD1+ TILs in metastatic in contrast with matched main TNBCs. Greater PD1+ CTLs, PD1+CD4+ helper T cells (PD1+TCONV) and all PD1+ T cells in sTILs, tTILs and whole stromal and tumor TILS (s+tTIL) have been all related to higher prognosis.
- In abstract, TIL subsets lower considerably in metastatic TNBCs in contrast with matched main. Hellogher PD1+ TILs are related to higher prognosis in early stage TNBCs. This discovering helps the appliance of immune checkpoint inhibitors early within the remedy of TNBCs
Tetranectin (CLEC3B) Antibody
Human Anti-Merozoite surface protein-1 (MSP-1; P. falciparum/malaria vaccine) IgG antiserum negative control |
970-360-01N |
Alpha Diagnostics |
1 ml |
EUR 196.8 |
Human Anti-Merozoite surface protein-1 (MSP-1; P. falciparum/malaria vaccine) IgG antiserum positive control |
970-360-02P |
Alpha Diagnostics |
1 ml |
EUR 270 |
Human Anti-Merozoite surface protein-1 (MSP-1; P. falciparum/malaria vaccine) IgM antiserum negative control |
970-370-01N |
Alpha Diagnostics |
1 ml |
EUR 196.8 |
Human Anti-Merozoite surface protein-1 (MSP-1; P. falciparum/malaria vaccine) IgM antiserum positive control |
970-370-02P |
Alpha Diagnostics |
1 ml |
EUR 270 |
Protein Kinase C, Panel, Western Blot Control (PKC) |
MBS652621-1Panel |
MyBiosource |
1Panel |
EUR 850 |
Protein Kinase C, Panel, Western Blot Control (PKC) |
MBS652621-5x1Panel |
MyBiosource |
5x1Panel |
EUR 3600 |
Bordetella bronchiseptica proteins (inactivated vaccine for dog) for ELISA |
BBV15-N-100 |
Alpha Diagnostics |
100 ug |
EUR 343.2 |
Rotavirus vaccine |
VAC-0352 |
Creative BioMart |
0.5ml |
EUR 1598.4 |
Description: Protein |
Core Panel Multi-Tumor control slides, set of 5 |
TS900 |
Innovex |
Set of 5 |
EUR 165 |
Core Panel Multi-Tumor control slides, set of 25 |
TS900-25 |
Innovex |
Set of 25 |
EUR 445 |
Breast Panel Multi-Tumor control slides, set of 5 |
TS901 |
Innovex |
Set of 5 |
EUR 165 |
Breast Panel Multi-Tumor control slides, set of 25 |
TS901-25 |
Innovex |
Set of 25 |
EUR 445 |
Control Animal Genomic DNA Panel, Set of any 5 species |
G-005 |
Zyagen |
5X0.025mg |
EUR 720 |
Control Animal Genomic DNA Panel, Set of any 10 species |
G-010 |
Zyagen |
10x0.025mg |
EUR 1193 |
Vaccine adjuvant-1 |
HY-160198 |
MedChemExpress |
Get quote |
Ask for price |
Description: Vaccine adjuvant-1 is an vaccine adjuvant is a vaccine adjuvant containing an oil phase, emulsifying agent and water[1]. |
Hepatitis A Vaccine |
SARS-401 |
Creative BioMart |
1 vial |
EUR 798.4 |
Description: Protein |
Yellow Fever Vaccine |
VAC-0339 |
Creative BioMart |
0.5ml |
EUR 1598.4 |
Description: Protein |
Recombinant flagellin FlicC vaccine adjuvant (TLR5 agonist); vaccine adjuvant |
AV-7010-50 |
Alpha Diagnostics |
50 ug |
EUR 1074 |
Rubella Virus Vaccine |
VAC-0323 |
Creative BioMart |
0.5ml |
EUR 1598.4 |
Description: Protein |
SARS-CoV-2 Spike RBD ELISA Kit (For Vaccine Development) |
RAS-A050 |
ACROBIOSYSTEMS |
96tests |
EUR 643.1 |
|
Description: The newly identified Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has posed a serious threat to human health. A rapid and effective assay kit detecting the levels of SARS-CoV-2 Spike Protein RBD is urgently needed to accelerate the development of COVID-19 vaccines. |
Rabies virus Glycoprotein G ELISA Kit (For Vaccine Development) |
RAS-A167 |
ACROBIOSYSTEMS |
96tests |
EUR 643.1 |
|
Description: Rabies virus (RABV), scientific name Rabies lyssavirus, is a deadly neurotropic virus that causes rabies in humans and animals. Rabies virus has an extremely wide host range and its transmission most often occur through the saliva of animals. Without intervention prior to disease progression, rabies has the highest case fatality of any infectious disease. RABV contains a single-stranded negative-sense R genome that encodes five structural proteins: nucleoprotein (N), phosphoprotein (P), matrix protein (M), glycoprotein (G), and R-dependent R polymerase (L). Among these viral proteins, the RABV glycoprotein (RABV-G) is a pivotal player mediating virus entry and the major target of neutralizing antibodies, thus a key factor for vaccine and drug design.A rapid and effective assay kit detecting the levels ofRABV-G is urgently needed to accelerate the development of RABV vaccines. |
Smallpox (Vaccinia) Vaccine, Live |
VLP-353 |
Creative BioMart |
1 vial |
EUR 798.4 |
Description: Protein |
Recombinant BCG Vaccine |
PFC-338 |
Creative BioMart |
1 vial |
EUR 798.4 |
Description: Protein |
Mycobacterium w. Vaccine |
COV2-370 |
Creative BioMart |
1 vial |
EUR 798.4 |
Description: Protein |
Saponin Vaccine Adjuvant |
VAdv-Ly0009 |
Creative Biolabs |
1 g |
EUR 1314 |
Description: Saponin Vaccine Adjuvant, plant-based vaccine adjuvant. |
SARS-CoV-2 Spike Protein ELISA Kit (For Vaccine Development) |
RAS-A039 |
ACROBIOSYSTEMS |
96tests |
EUR 643.1 |
|
Description: The newly identified Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has posed a serious threat to human health. A rapid and effective assay kit detecting the levels of SARS-CoV-2 Spike protein is urgently needed to accelerate the development of COVID-19 vaccines. |
Rabbit Anti-West Nile Virus vaccine (WNV, Recombitek/DNA vaccine) antiserum |
WNV13-S |
Alpha Diagnostics |
100 ul |
EUR 548.4 |
Customized Organic Acids Panel-2 in Urine Lyophilized Control Level 1 |
ZV-3066-02K1-20 |
Zivak Technologies |
1 x 3mL |
Ask for price |
Vaccine adjuvant-1 (GMP) |
HY-160198G |
MedChemExpress |
Get quote |
Ask for price |
Description: Vaccine adjuvant-1 GMP is Vaccine adjuvant-1 produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Vaccine adjuvant-1 is an vaccine adjuvant is a vaccine adjuvant containing an oil phase, emulsifying agent and water[1]. |
Moderna COVID-19 Vaccine |
H7N7-319 |
Creative BioMart |
1 vial |
EUR 798.4 |
Description: Protein |
MUC1 Dendritic Cell Vaccine |
VAC-0369 |
Creative BioMart |
0.5ml |
EUR 1598.4 |
Description: Protein |
SARS-CoV-2 Spike RBD (XBB.1.5) ELISA Kit (For Vaccine Development) |
RAS-A146 |
ACROBIOSYSTEMS |
96tests |
EUR 861.1 |
|
Description: The newly identified Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has posed a serious threat to human health. A rapid and effective assay kit detecting the levels of SARS-CoV-2 Spike RBD is urgently needed to accelerate the development of COVID-19 vaccines. |
SARS-CoV-2 Spike Trimer (XBB.1.5) ELISA Kit (For Vaccine Development) |
RAS-A145 |
ACROBIOSYSTEMS |
96tests |
EUR 861.1 |
|
Description: The newly identified Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has posed a serious threat to human health. A rapid and effective assay kit detecting the levels of SARS-CoV-2 Spike Trimer is urgently needed to accelerate the development of COVID-19 vaccines. |
SARS-CoV-2 Spike Trimer (XBB.1) ELISA Kit (For Vaccine Development) |
RAS-A149 |
ACROBIOSYSTEMS |
96tests |
EUR 861.1 |
|
Description: The newly identified Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has posed a serious threat to human health. A rapid and effective assay kit detecting the levels of SARS-CoV-2 Spike Trimer is urgently needed to accelerate the development of COVID-19 vaccines. |
Dengue tetravalent vaccine, live |
VZV-421 |
Creative BioMart |
1 vial |
EUR 798.4 |
Description: Protein |
Recombinant Hepatitis B Vaccine |
NG2-351 |
Creative BioMart |
1 vial |
EUR 798.4 |
Description: Protein |
Pam2CSK4 vaccine adjuvant; Biotin conjugate |
AV-9020-B |
Alpha Diagnostics |
1 mg |
EUR 489.6 |
Pam2CSK4 vaccine adjuvant; Biotin conjugate |
AV-9020-B-100 |
Alpha Diagnostics |
100 ug |
EUR 196.8 |
Typhoid Vi polysaccharide vaccine |
VAC-0357 |
Creative BioMart |
0.5ml |
EUR 1598.4 |
Description: Protein |
Recombinant Varicella Zoster Vaccine |
VAC-0270 |
Creative BioMart |
0.5ml |
EUR 1598.4 |
Description: Protein |
BNT162c2 SARS-CoV-2 Vaccine |
INB-326 |
Creative BioMart |
1 vial |
EUR 798.4 |
Description: Protein |
Adenovirus type 7 vaccine live |
MPC-341 |
Creative BioMart |
1 vial |
EUR 798.4 |
Description: Protein |

Detection of Germline Mutations in Breast Most cancers Sufferers with Medical Options of Hereditary Most cancers Syndrome Utilizing a Multi-Gene Panel Take a look at.
Hereditary most cancers syndrome signifies that inherited genetic mutations can improve an individual’s danger of creating most cancers.
Tetranectin Polyclonal Antibody
We assessed the frequency of germline mutations utilizing an NGS-based multiple-gene panel containing 64-cancer predisposing genes in Korean breast most cancers sufferers with medical options of hereditary breast and ovarian most cancers syndrome (HBOC).A complete of 64 genes related to hereditary most cancers syndrome have been chosen for improvement of an NGS-based multi-gene panel.
Human Tetranectin (CLEC3B) ELISA Package
Focused sequencing utilizing the multi-gene panel was carried out to establish germline mutations in 496 breast most cancers sufferers with medical options of HBOC who underwent breast most cancers surgical procedure between January 2002 and December 2017.Of 496 sufferers, 95 sufferers (19.2%) have been discovered to have 48 deleterious germline mutations in 16 most cancers susceptibility genes.
Human Tetranectin ELISA Kit |
MBS2882980-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 4080 |
Human Tetranectin ELISA Kit |
MBS2882980-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 390 |
Human Tetranectin ELISA Kit |
MBS2882980-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 2220 |
Human Tetranectin ELISA Kit |
MBS2882980-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 520 |
Human Tetranectin ELISA Kit |
MBS762655-10x96StripWells |
MyBiosource |
10x96-Strip-Wells |
EUR 3900 |
Human Tetranectin ELISA Kit |
MBS762655-48StripWells |
MyBiosource |
48-Strip-Wells |
EUR 340 |
Human Tetranectin ELISA Kit |
MBS762655-5x96StripWells |
MyBiosource |
5x96-Strip-Wells |
EUR 2045 |
Human Tetranectin ELISA Kit |
MBS762655-96StripWells |
MyBiosource |
96-Strip-Wells |
EUR 455 |
Human Tetranectin ELISA Kit |
MBS824758-5x96Tests |
MyBiosource |
5x96Tests |
EUR 2880 |
Human Tetranectin ELISA Kit |
MBS824758-96Tests |
MyBiosource |
96Tests |
EUR 645 |
Human Tetranectin ELISA Kit |
MBS9427171-5x96Tests |
MyBiosource |
5x96Tests |
EUR 2820 |
Human Tetranectin ELISA Kit |
MBS9427171-96Tests |
MyBiosource |
96Tests |
EUR 615 |
Human Tetranectin Antibody Pair Set |
ABPR-ZB221 |
Creative Diagnostics |
5 plates, 15 plates |
Ask for price |
Description: Quantitative determination of Human Tetranectin |
ELISA Kit for Human Tetranectin |
E1411h |
EIAab |
96T |
EUR 387.4 |
Tetranectin |
AP78991 |
SAB |
1mg |
EUR 2640 |
|
Tetranectin |
AP88122 |
SAB |
1mg |
EUR 2640 |
|
Tetranectin |
AP88508 |
SAB |
1mg |
EUR 2640 |
|
Tetranectin |
E8ET7108-45 |
EnoGene |
100ul |
EUR 275 |
Description: Available in various conjugation types. |
Tetranectin |
MBS8565864-01mLAF405L |
MyBiosource |
0.1mL(AF405L) |
EUR 565 |
Tetranectin |
MBS8565864-01mLAF405S |
MyBiosource |
0.1mL(AF405S) |
EUR 565 |
Tetranectin |
MBS8565864-01mLAF610 |
MyBiosource |
0.1mL(AF610) |
EUR 565 |
Tetranectin |
MBS8565864-01mLAF635 |
MyBiosource |
0.1mL(AF635) |
EUR 565 |
Recombinant Human Tetranectin (CLEC3B) |
CSB-EP005531HU |
Cusabio |
11018 mg |
Ask for price |
Recombinant Human Tetranectin (CLEC3B) |
CSB-EP005531HU-100ug |
Cusabio |
100ug |
Ask for price |
|
Description: 22-202aa |
Recombinant Human Tetranectin (CLEC3B) |
CSB-EP005531HU-1mg |
Cusabio |
1mg |
Ask for price |
|
Description: 22-202aa |
Recombinant Human Tetranectin (CLEC3B) |
CSB-EP005531HU-20ug |
Cusabio |
20ug |
Ask for price |
|
Description: 22-202aa |
Recombinant Human Tetranectin (CLEC3B) |
MBS965439-002mgBaculovirus |
MyBiosource |
0.02mg(Baculovirus) |
EUR 1100 |
Recombinant Human Tetranectin (CLEC3B) |
MBS965439-002mgEColi |
MyBiosource |
0.02mg(E-Coli) |
EUR 700 |
Recombinant Human Tetranectin (CLEC3B) |
MBS965439-002mgYeast |
MyBiosource |
0.02mg(Yeast) |
EUR 855 |
Recombinant Human Tetranectin (CLEC3B) |
MBS965439-01mgEColi |
MyBiosource |
0.1mg(E-Coli) |
EUR 810 |
Recombinant Human Tetranectin (CLEC3B) |
MBS965439-01mgYeast |
MyBiosource |
0.1mg(Yeast) |
EUR 1000 |
Mouse anti Human CLEC3B/Tetranectin Monoclonal Antibody |
MBS2543718-006mL |
MyBiosource |
0.06mL |
EUR 250 |
Mouse anti Human CLEC3B/Tetranectin Monoclonal Antibody |
MBS2543718-012mL |
MyBiosource |
0.12mL |
EUR 370 |
Mouse anti Human CLEC3B/Tetranectin Monoclonal Antibody |
MBS2543718-02mL |
MyBiosource |
0.2mL |
EUR 550 |
Human Tetranectin(CLEC3B) ELISA kit |
CSB-EL005531HU-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
Description: Quantitativesandwich ELISA kit for measuring Human Tetranectin (CLEC3B) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Human Tetranectin(CLEC3B) ELISA kit |
CSB-EL005531HU-48T |
Cusabio |
48T |
EUR 338.81 |
|
Description: Homo sapiens (Human) |
Human Tetranectin(CLEC3B) ELISA kit |
1-CSB-EL005531HU |
Cusabio |
-
Ask for price
-
Ask for price
-
Ask for price
|
- 1 plate of 96 wells
- 5 plates of 96 wells each
- 10 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Human Tetranectin(CLEC3B) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Human Tetranectin(CLEC3B) ELISA kit |
CSB-EL005531HU-96T |
Cusabio |
96T |
EUR 521.25 |
|
Description: Homo sapiens (Human) |
Human Tetranectin(CLEC3B) ELISA kit |
E01A8123 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Human Tetranectin (CLEC3B) ELISA Kit |
abx252170-96tests |
Abbexa |
96 tests |
EUR 801.6 |
|
Human Tetranectin(CLEC3B) ELISA kit |
E01T0030-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Human Tetranectin(CLEC3B) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Tetranectin(CLEC3B) ELISA kit |
E01T0030-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Human Tetranectin(CLEC3B) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Tetranectin(CLEC3B) ELISA kit |
E01T0030-48wellsplate |
BlueGene |
48 wells plate |
EUR 280 |
Human Tetranectin(CLEC3B) ELISA kit |
E01T0030-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Human Tetranectin(CLEC3B) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Tetranectin(CLEC3B) ELISA kit |
E01T0030-96wellsplate |
BlueGene |
96 wells plate |
EUR 405 |
Human Tetranectin (CLEC3B) ELISA Kit |
IHUCLEC3BKT |
Innovative research |
each |
EUR 702 |
|
Description: Human Tetranectin (CLEC3B) ELISA Kit |
Human Tetranectin,CLEC3B ELISA KIT |
JOT-EK6262Hu |
Jotbody |
96 wells |
Ask for price |
Description: Human |
Human Tetranectin (CLEC3B) ELISA Kit |
MBS139558-1Kit |
MyBiosource |
1Kit |
EUR 755 |
Human Tetranectin (CLEC3B) ELISA Kit |
MBS139558-5x1Kit |
MyBiosource |
5x1Kit |
EUR 3455 |
The deleterious mutations have been present in 39 of 250 sufferers (15.6%) who had breast most cancers and one other main most cancers, 38 of 169 sufferers (22.5%) who had a household historical past of breast most cancers (≥ 2 family members), 16 of 57 sufferers (28.1%) who had bilateral breast most cancers, and 29 of 84 sufferers (34.5%) who have been recognized with breast most cancers at youthful than 40 years of age.
Human CellExp? CLEC3B / Tetranectin, Human recombinant
Of the 95 sufferers with deleterious mutations, 60 sufferers (63.2%) had BRCA1/2 mutations and 38 sufferers (40.0%) had non-BRCA1/2 mutations. We detected 2 novel deleterious mutations in BRCA2 and MLH1.NGS-based multiple-gene panel testing improved the detection charges of deleterious mutations and supplied a cheap most cancers danger evaluation.