Multi–panel immunofluorescence evaluation of tumor infiltrating lymphocytes in triple adverse breast most cancers: Evolution of tumor immune profiles and affected person prognosis.
- The evolutionary adjustments in immune profiles of triple adverse breast most cancers (TNBC) aren’t properly understood, though it’s identified that immune checkpoint inhibitors have diminished exercise in closely pre-treated TNBC sufferers. This examine was designed to characterize immune profile adjustments of longitudinal tumor specimens by learning immune subsets of tumor infiltrating lymphocytes (TILs) in paired main and metastatic TNBC in a cohort of “poor end result” (relapsed inside 5 years) sufferers.
- Immune profiles of TNBCs in a cohort of “good end result” (no relapse inside 5 years) sufferers have been additionally analyzed. Immune subsets have been characterised for CD4, CD8, FOXP3, CD20, CD33, and PD1 utilizing immuno-fluorescence staining in stroma, tumor, and mixed stroma and tumor tissue. TIL subsets in “good end result” versus “poor end result” sufferers have been additionally analyzed. In contrast with main, metastatic TNBCs had considerably decrease TILs by hematoxylin and eosin (H&E) staining.
HAV HAV P2C recombinant antigen
- Stromal TILs (sTILs), however not tumoral TILs (tTILs) had considerably lowered cytotoxic CD8+ T cells (CTLs), PD1+ CTLs, and whole PD1+ TILs in metastatic in contrast with matched main TNBCs. Greater PD1+ CTLs, PD1+CD4+ helper T cells (PD1+TCONV) and all PD1+ T cells in sTILs, tTILs and whole stromal and tumor TILS (s+tTIL) have been all related to higher prognosis.
- In abstract, TIL subsets lower considerably in metastatic TNBCs in contrast with matched main. Hellogher PD1+ TILs are related to higher prognosis in early stage TNBCs. This discovering helps the appliance of immune checkpoint inhibitors early within the remedy of TNBCs
Tetranectin (CLEC3B) Antibody
Breast Panel Multi-Tumor control slides |
TS901-25 |
Innovex |
Set of 25 |
EUR 485 |
HAV HAV P2C recombinant antigen |
00165-V-01mg |
Virogen |
0,1 mg |
EUR 267.5 |
|
Description: HAV HAV P2C recombinant antigen a.a. 1121-1234. |
HAV HAV P2C recombinant antigen |
00165-V-1000ug |
Virogen |
1000 ug |
EUR 1282.5 |
|
Description: HAV HAV P2C recombinant antigen a.a. 1121-1234. |
anti-IVD |
YF-PA12811 |
Abfrontier |
50 ug |
EUR 363 |
Description: Mouse polyclonal to IVD |
anti-IVD |
YF-PA12812 |
Abfrontier |
100 ug |
EUR 403 |
Description: Rabbit polyclonal to IVD |
IVD antibody |
70R-18039 |
Fitzgerald |
50 ul |
EUR 435 |
Description: Rabbit polyclonal IVD antibody |
IVD antibody |
70R-13603 |
Fitzgerald |
100 ul |
EUR 457 |
Description: Affinity purified Rabbit polyclonal IVD antibody |
IVD antibody |
10R-4491 |
Fitzgerald |
100 ul |
EUR 691 |
Description: Mouse monoclonal IVD antibody |
IVD Antibody |
DF12284 |
Affbiotech |
200ul |
EUR 304 |
Description: IVD antibody detects endogenous levels of IVD. |
IVD Antibody |
1-CSB-PA011921GA01HU |
Cusabio |
|
|
|
Description: A polyclonal antibody against IVD. Recognizes IVD from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC |
IVD Antibody |
1-CSB-PA011921LA01HU |
Cusabio |
|
|
|
Description: A polyclonal antibody against IVD. Recognizes IVD from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:500-1:1000 |
IVD antibody |
22140-100ul |
SAB |
100ul |
EUR 390 |
HAV Antigen |
E61H00101 |
EnoGene |
1mg |
EUR 611 |
HAV Protein |
abx069838-1ml |
Abbexa |
1 ml |
EUR 314 |
|
HAV Protein |
abx069839-1ml |
Abbexa |
1 ml |
EUR 982 |
|
IVD, Human Recombinant |
P1577-100 |
Biovision |
100 µg |
EUR 510 |
IVD, Human Recombinant |
P1577-20 |
Biovision |
20 µg |
EUR 156 |
IVD Blocking Peptide |
DF12284-BP |
Affbiotech |
1mg |
EUR 195 |
IVD cloning plasmid |
CSB-CL011921HU-10ug |
Cusabio |
10ug |
EUR 465 |
|
Description: A cloning plasmid for the IVD gene. |
IVD Rabbit pAb |
A15281-100ul |
Abclonal |
100 ul |
EUR 308 |
IVD Rabbit pAb |
A15281-200ul |
Abclonal |
200 ul |
EUR 459 |
IVD Rabbit pAb |
A15281-20ul |
Abclonal |
20 ul |
EUR 183 |
IVD Rabbit pAb |
A15281-50ul |
Abclonal |
50 ul |
EUR 223 |
Human IVD Antibody |
33170-05111 |
AssayPro |
150 ug |
EUR 261 |
IVD Polyclonal Antibody |
28898-100ul |
SAB |
100ul |
EUR 252 |
IVD Polyclonal Antibody |
28898-50ul |
SAB |
50ul |
EUR 187 |
anti- IVD antibody |
FNab04426 |
FN Test |
100µg |
EUR 505.25 |
|
Description: Antibody raised against IVD |
anti- IVD antibody |
FNab04427 |
FN Test |
100µg |
EUR 585 |
|
Description: Antibody raised against IVD |
Anti-IVD antibody |
STJ117476 |
St John's Laboratory |
100 µl |
EUR 277 |
Description: Isovaleryl-CoA dehydrogenase (IVD) is a mitochondrial matrix enzyme that catalyzes the third step in leucine catabolism. The genetic deficiency of IVD results in an accumulation of isovaleric acid, which is toxic to the central nervous system and leads to isovaleric acidemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Bordetella bronchiseptica proteins (inactivated vaccine for dog) for ELISA |
BBV15-N-100 |
Alpha Diagnostics |
100 ug |
EUR 286 |
HAV VP3 antibody |
10R-10488 |
Fitzgerald |
100 ug |
EUR 435 |
Description: Mouse monoclonal HAV VP3 antibody |
HAV VP3 antibody |
10R-10489 |
Fitzgerald |
100 ug |
EUR 435 |
Description: Mouse monoclonal HAV VP3 antibody |
HAV VP1 antibody |
10R-10520 |
Fitzgerald |
100 ug |
EUR 435 |
Description: Mouse monoclonal HAV VP1 antibody |
HAV VP1 antibody |
10R-10521 |
Fitzgerald |
100 ug |
EUR 435 |
Description: Mouse monoclonal HAV VP1 antibody |
HAV VP1 antibody |
10R-10522 |
Fitzgerald |
100 ug |
EUR 435 |
Description: Mouse monoclonal HAV VP1 antibody |
HAV P3C Protein |
abx060523-1mg |
Abbexa |
1 mg |
EUR 1511 |
|
HAV VP1 Protein |
abx060524-1mg |
Abbexa |
1 mg |
EUR 1525 |
|
HAV VP3 Protein |
abx060526-1mg |
Abbexa |
1 mg |
EUR 1525 |
|
HAV VP3 Antibody |
abx018272-100ug |
Abbexa |
100 ug |
EUR 384 |
|
HAV VP3 Antibody |
abx018273-100ug |
Abbexa |
100 ug |
EUR 384 |
|
HAV VP1 Antibody |
abx018304-100ug |
Abbexa |
100 ug |
EUR 384 |
|
HAV VP1 Antibody |
abx018305-100ug |
Abbexa |
100 ug |
EUR 384 |
|
HAV VP1 Antibody |
abx018306-100ug |
Abbexa |
100 ug |
EUR 384 |
|
HAV monoclonal antibody |
VAnt-Lsx001-1mg |
Creative Biolabs |
1 mg |
EUR 2577 |
Description: HAV, Monoclonal Antibody; contains a high concentration of viral antibody. |
HAV monoclonal antibody |
VAnt-Lsx001-5mg |
Creative Biolabs |
5mg |
EUR 4970 |
Description: HAV, Monoclonal Antibody; contains a high concentration of viral antibody. |
HAV antibody (HRP) |
VAnt-Lsx014-1mg |
Creative Biolabs |
1 mg |
EUR 3268 |
Description: HRP is conjugated to HAV antibody to detect the target molecule. |
HAV antibody (HRP) |
VAnt-Lsx014-5mg |
Creative Biolabs |
5mg |
EUR 6163 |
Description: HRP is conjugated to HAV antibody to detect the target molecule. |
Saponin Vaccine Adjuvant |
VAdv-Ly0009 |
Creative Biolabs |
1 g |
EUR 1095 |
Description: Saponin Vaccine Adjuvant, plant-based vaccine adjuvant. |

Detection of Germline Mutations in Breast Most cancers Sufferers with Medical Options of Hereditary Most cancers Syndrome Utilizing a Multi-Gene Panel Take a look at.
Hereditary most cancers syndrome signifies that inherited genetic mutations can improve an individual’s danger of creating most cancers.
Tetranectin Polyclonal Antibody
We assessed the frequency of germline mutations utilizing an NGS-based multiple-gene panel containing 64-cancer predisposing genes in Korean breast most cancers sufferers with medical options of hereditary breast and ovarian most cancers syndrome (HBOC).A complete of 64 genes related to hereditary most cancers syndrome have been chosen for improvement of an NGS-based multi-gene panel.
Human Tetranectin (CLEC3B) ELISA Package
Focused sequencing utilizing the multi-gene panel was carried out to establish germline mutations in 496 breast most cancers sufferers with medical options of HBOC who underwent breast most cancers surgical procedure between January 2002 and December 2017.Of 496 sufferers, 95 sufferers (19.2%) have been discovered to have 48 deleterious germline mutations in 16 most cancers susceptibility genes.
Anti-Tetranectin Antibody |
A08805 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal Antibody for Tetranectin Antibody (CLEC3B) detection.tested for IHC in Human, Mouse. |
Anti-Tetranectin antibody |
STJ98805 |
St John's Laboratory |
200 µl |
EUR 197 |
Description: Rabbit polyclonal to Tetranectin. |
Rabbit Polyclonal antibody Anti-CRBN |
Anti-CRBN |
ImmunoStep |
50 µg |
EUR 349 |
Tetranectin Antibody |
49915-100ul |
SAB |
100ul |
EUR 333 |
Tetranectin Antibody |
49915-50ul |
SAB |
50ul |
EUR 239 |
Recombinant Human Tetranectin Protein |
RP00991 |
Abclonal |
10 μg |
EUR 155 |
Tetranectin Polyclonal Antibody |
ES8742-100ul |
ELK Biotech |
100ul |
EUR 279 |
Description: A Rabbit Polyclonal antibody against Tetranectin from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA |
Tetranectin Polyclonal Antibody |
ES8742-50ul |
ELK Biotech |
50ul |
EUR 207 |
Description: A Rabbit Polyclonal antibody against Tetranectin from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA |
Tetranectin (CLEC3B) Antibody |
20-abx125686 |
Abbexa |
-
EUR 411.00
-
EUR 592.00
-
EUR 182.00
-
EUR 314.00
|
-
100 ul
-
200 ul
-
20 ul
-
50 ul
|
|
Tetranectin Polyclonal Antibody |
ABP60656-003ml |
Abbkine |
0.03ml |
EUR 158 |
|
Description: A polyclonal antibody for detection of Tetranectin from Human, Mouse. This Tetranectin antibody is for IHC-P, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human Tetranectin protein at amino acid sequence of 11-60 |
Tetranectin Polyclonal Antibody |
ABP60656-01ml |
Abbkine |
0.1ml |
EUR 289 |
|
Description: A polyclonal antibody for detection of Tetranectin from Human, Mouse. This Tetranectin antibody is for IHC-P, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human Tetranectin protein at amino acid sequence of 11-60 |
Tetranectin Polyclonal Antibody |
ABP60656-02ml |
Abbkine |
0.2ml |
EUR 414 |
|
Description: A polyclonal antibody for detection of Tetranectin from Human, Mouse. This Tetranectin antibody is for IHC-P, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human Tetranectin protein at amino acid sequence of 11-60 |
Tetranectin (CLEC3B) Antibody |
20-abx004912 |
Abbexa |
-
EUR 411.00
-
EUR 592.00
-
EUR 182.00
-
EUR 314.00
|
-
100 ul
-
200 ul
-
20 ul
-
50 ul
|
|
Tetranectin Rabbit mAb |
A4387-100ul |
Abclonal |
100 ul |
EUR 410 |
Tetranectin Rabbit mAb |
A4387-200ul |
Abclonal |
200 ul |
EUR 571 |
Tetranectin Rabbit mAb |
A4387-20ul |
Abclonal |
20 ul |
EUR 221 |
Tetranectin Rabbit mAb |
A4387-50ul |
Abclonal |
50 ul |
EUR 287 |
Tetranectin (CLEC3B) Antibody |
20-abx320279 |
Abbexa |
|
|
|
Tetranectin (CLEC3B) Antibody |
20-abx225113 |
Abbexa |
-
EUR 370.00
-
EUR 606.00
-
EUR 314.00
|
|
|
Tetranectin (CLEC3B) Antibody |
abx231752-100ug |
Abbexa |
100 ug |
EUR 509 |
|
Tetranectin (CLEC3B) Antibody |
abx145920-100ug |
Abbexa |
100 ug |
EUR 391 |
|
Tetranectin Conjugated Antibody |
C49915 |
SAB |
100ul |
EUR 397 |
Tetranectin Polyclonal Antibody |
46862-100ul |
SAB |
100ul |
EUR 252 |
Tetranectin Polyclonal Antibody |
46862-50ul |
SAB |
50ul |
EUR 187 |
Human Tetranectin(CLEC3B) ELISA kit |
E01T0030-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Human Tetranectin(CLEC3B) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Tetranectin(CLEC3B) ELISA kit |
E01T0030-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A competitive ELISA for quantitative measurement of Human Tetranectin(CLEC3B) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Tetranectin(CLEC3B) ELISA kit |
E01T0030-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Human Tetranectin(CLEC3B) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Tetranectin(CLEC3B) ELISA kit |
CSB-EL005531HU-24T |
Cusabio |
1 plate of 24 wells |
EUR 165 |
|
Description: Quantitativesandwich ELISA kit for measuring Human Tetranectin (CLEC3B) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Human Tetranectin(CLEC3B) ELISA kit |
1-CSB-EL005531HU |
Cusabio |
-
EUR 804.00
-
EUR 5099.00
-
EUR 2704.00
|
-
1 plate of 96 wells
-
10 plates of 96 wells each
-
5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Human Tetranectin(CLEC3B) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Human CLEC3B/ Tetranectin ELISA Kit |
E0507Hu |
Sunlong |
1 Kit |
EUR 571 |
Human Tetranectin (CLEC3B) ELISA Kit |
abx252170-96tests |
Abbexa |
96 tests |
EUR 668 |
|
ELISA kit for Human Tetranectin |
EK3337 |
SAB |
96 tests |
EUR 553 |
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Tetranectin in samples from serum, plasma, tissue homogenates and other biological fluids. |
Human CLEC3B(Tetranectin) ELISA Kit |
EH0279 |
FN Test |
96T |
EUR 567.6 |
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.469 ng/ml |
Human CellExp? CLEC3B / Tetranectin, Human recombinant |
P1058-10 |
Biovision |
|
EUR 153 |
Human CellExp? CLEC3B / Tetranectin, Human recombinant |
P1058-50 |
Biovision |
|
EUR 501 |
Polyclonal Goat anti-GST α-form |
GST-ANTI-1 |
Detroit R&D |
50 uL |
EUR 280 |
Polyclonal Goat anti-GST μ-form |
GST-ANTI-2 |
Detroit R&D |
50 uL |
EUR 280 |
Polyclonal Goat anti-GST p-form |
GST-ANTI-3 |
Detroit R&D |
50 uL |
EUR 280 |
Tetranectin Polyclonal Conjugated Antibody |
C46862 |
SAB |
100ul |
EUR 397 |
Recombinant Human CLEC3B/Tetranectin (C-6His) |
C453-10ug |
Novoprotein |
10ug |
EUR 131 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
Recombinant Human CLEC3B/Tetranectin (C-6His) |
C453-1mg |
Novoprotein |
1mg |
EUR 2283 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
Recombinant Human CLEC3B/Tetranectin (C-6His) |
C453-500ug |
Novoprotein |
500ug |
EUR 1613 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
Recombinant Human CLEC3B/Tetranectin (C-6His) |
C453-50ug |
Novoprotein |
50ug |
EUR 273 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
Tetranectin/CLEC3B ELISA Kit (Human) (OKBB00562) |
OKBB00562 |
Aviva Systems Biology |
96 Wells |
EUR 505 |
Description: Description of target: Tetranectin, also called TNA, is a protein that in humans is encoded by the CLEC3B gene. It is mapped to 3p21.31. Tetranectin, a tetrameric protein isolated from human plasma, has 4 identical and noncovalently bound polypeptide chains, each of 181 amino acid residues. It has a specific binding affinity for sulfated polysaccharides and the kringle 4 of plasminogen. The plasma concentration of tetranectin is reduced in patients with various malignancies. Tetranectin is a plasminogen-binding protein that is induced during the mineralization phase of osteogenesis. Thus, tetranectin is a candidate gene for human disorders affecting bone and connective tissue.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: <= 10 pg/mL |
Mouse Tetranectin(CLEC3B) ELISA kit |
E03T0030-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Mouse Tetranectin(CLEC3B) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Tetranectin(CLEC3B) ELISA kit |
E03T0030-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A competitive ELISA for quantitative measurement of Mouse Tetranectin(CLEC3B) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Tetranectin(CLEC3B) ELISA kit |
E03T0030-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Mouse Tetranectin(CLEC3B) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Tetranectin(CLEC3B) ELISA kit |
E02T0030-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Rat Tetranectin(CLEC3B) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Tetranectin(CLEC3B) ELISA kit |
E02T0030-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A competitive ELISA for quantitative measurement of Rat Tetranectin(CLEC3B) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Tetranectin(CLEC3B) ELISA kit |
E02T0030-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Rat Tetranectin(CLEC3B) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
The deleterious mutations have been present in 39 of 250 sufferers (15.6%) who had breast most cancers and one other main most cancers, 38 of 169 sufferers (22.5%) who had a household historical past of breast most cancers (≥ 2 family members), 16 of 57 sufferers (28.1%) who had bilateral breast most cancers, and 29 of 84 sufferers (34.5%) who have been recognized with breast most cancers at youthful than 40 years of age.
Human CellExp? CLEC3B / Tetranectin, Human recombinant
Of the 95 sufferers with deleterious mutations, 60 sufferers (63.2%) had BRCA1/2 mutations and 38 sufferers (40.0%) had non-BRCA1/2 mutations. We detected 2 novel deleterious mutations in BRCA2 and MLH1.NGS-based multiple-gene panel testing improved the detection charges of deleterious mutations and supplied a cheap most cancers danger evaluation.