EGFR mutations in lung most cancers: correlation with medical response to gefitinib remedy.
- Receptor tyrosine kinase genes had been sequenced in non-small cell lung most cancers (NSCLC) and matched regular tissue. Somatic mutations of the epidermal progress issue receptor gene EGFR had been present in 15of 58 unselected tumors from Japan and 1 of 61 from america. Remedy with the EGFR kinase inhibitor gefitinib (Iressa) causes tumor regression in some sufferers with NSCLC, extra ceaselessly in Japan.
- EGFR mutations had been present in extra lung most cancers samples from U.S. sufferers who responded to gefitinib remedy and in a lung adenocarcinoma cell line that was hypersensitive to progress inhibition by gefitinib, however not in gefitinib-insensitive tumors or cell strains. These outcomes recommend that EGFR mutations could predict sensitivity to gefitinib.
IRINOTECAN HYDROCHLORIDE
- The HER-2/neu oncogene is a member of the erbB-like oncogene household, and is related to, however distinct from, the epidermal progress issue receptor. This gene has been proven to be amplified in human breast most cancers cell strains.
- Within the present research, alterations of the gene in 189 primary human breast cancers had been investigated. HER-2/neu was discovered to be amplified from 2- to better than 20-fold in 30% of the tumors. Correlation of gene amplification with a number of illness parameters was evaluated. Amplification of the HER-2/neu gene was a major predictor of each total survival and time to relapse in sufferers with breast most cancers. It retained its significance even when changes had been made for different identified prognostic components.
TOMATIDINE HYDROCHLORIDE | PHENFORMIN HYDROCHLORIDE
- Furthermore, HER-2/neu amplification hadvert better prognostic worth than most at present used prognostic components, together with hormonal-receptor standing, in lymph node-positive illness. These knowledge point out that this gene could play a job within the biologic behavior and/or pathogenesis of human breast most cancers.
 Quizartinib |
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| HY-13001 | MedChemExpress | 10mM/1mL | EUR 134 |
Quizartinib |
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| 2008-1 | Biovision | EUR 147 | |
Quizartinib |
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| 2008-5 | Biovision | EUR 419 | |
 Vatalanib, Dihydrochloride Salt, >99% |
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| BC099-025 | GenDepot | 25mg | EUR 205 |
Vatalanib, Dihydrochloride Salt, >99% |
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| BC099-100 | GenDepot | 100mg | EUR 261 |
) Quizartinib (AC220) |
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| A5793-100 | ApexBio | 100 mg | EUR 537 |
Quizartinib (AC220) |
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| A5793-25 | ApexBio | 25 mg | EUR 241 |
Quizartinib (AC220) |
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| A5793-5 | ApexBio | 5 mg | EUR 113 |
Quizartinib (AC220) |
|||
| A5793-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 131 |
Quizartinib (AC220) |
|||
| A5793-S | ApexBio | Evaluation Sample | EUR 81 |
 H 89, Dihydrochloride Salt, >99% |
|||
| BC038-010 | GenDepot | 10mg | EUR 232 |
H 89, Dihydrochloride Salt, >99% |
|||
| BC038-025 | GenDepot | 25mg | EUR 367 |
H 89, Dihydrochloride Salt, >99% |
|||
| BC038-100 | GenDepot | 100mg | EUR 887 |
 HA-1077, Dihydrochloride Salt, >99% |
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| BC039-050 | GenDepot | 50mg | EUR 313 |
HA-1077, Dihydrochloride Salt, >99% |
|||
| BC039-100 | GenDepot | 100mg | EUR 408 |
HA-1077, Dihydrochloride Salt, >99% |
|||
| BC039-200 | GenDepot | 200mg | Ask for price |
HA-1077, Dihydrochloride Salt, >99% |
|||
| BC039-500 | GenDepot | 500mg | Ask for price |
) Dihydrorhodamine 123, dihydrochloride salt: (10mg) |
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| 10056 | Biotium | 10MG | EUR 191 |
) Dihydrorhodamine 123, dihydrochloride salt: (20x500ug) |
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| 10056-1 | Biotium | 20x500uG | EUR 234 |
-Cephaeline (dihydrochloride)) (-)-Cephaeline (dihydrochloride) |
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| HY-N2260 | MedChemExpress | 5mg | EUR 340 |
 JPH203 Dihydrochloride |
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| HY-U00445 | MedChemExpress | 100mg | EUR 946 |
) Levocetirizine (dihydrochloride) |
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| HY-W010841 | MedChemExpress | 25mg | EUR 160 |
 Ethambutol dihydrochloride |
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| E005-100G | TOKU-E | 100 g | EUR 424 |
Ethambutol dihydrochloride |
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| E005-25G | TOKU-E | 25 g | EUR 143 |
 Cefotiam Dihydrochloride |
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| C095-100MG | TOKU-E | 100 mg | EUR 232 |
Cefotiam Dihydrochloride |
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| C095-50MG | TOKU-E | 50 mg | EUR 144 |
 Chlorhexidine Dihydrochloride |
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| C157-25G | TOKU-E | 25 g | EUR 185 |
Chlorhexidine Dihydrochloride |
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| C157-5G | TOKU-E | 5 g | EUR 72 |
) MRT68921 (dihydrochloride) |
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| HY-100006A | MedChemExpress | 10mM/1mL | EUR 141 |
) Dilazep (dihydrochloride) |
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| HY-100957 | MedChemExpress | 10mM/1mL | EUR 196 |
) ZK756326 (dihydrochloride) |
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| HY-101038A | MedChemExpress | 100mg | EUR 725 |
) Veliparib (dihydrochloride) |
|||
| HY-10130 | MedChemExpress | 200mg | EUR 766 |
) PAβN (dihydrochloride) |
|||
| HY-101444A | MedChemExpress | 10mM/1mL | EUR 129 |
) IT1t (dihydrochloride) |
|||
| HY-101458A | MedChemExpress | 10mg | EUR 257 |
) Lesopitron (dihydrochloride) |
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| HY-101609 | MedChemExpress | 20mg | EUR 2530 |
) UAMC00039 (dihydrochloride) |
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| HY-101769 | MedChemExpress | 10mM/1mL | EUR 166 |
) Tirbanibulin (dihydrochloride) |
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| HY-10340A | MedChemExpress | 50mg | EUR 698 |
 LCL521 dihydrochloride |
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| HY-103593A | MedChemExpress | 10mg | EUR 681 |
) Canertinib (dihydrochloride) |
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| HY-10367A | MedChemExpress | 10mM/1mL | EUR 126 |
) Daclatasvir (dihydrochloride) |
|||
| HY-10465 | MedChemExpress | 100mg | EUR 153 |
) JDTic (dihydrochloride) |
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| HY-10487 | MedChemExpress | 50mg | EUR 1251 |
) Lexibulin (dihydrochloride) |
|||
| HY-10498A | MedChemExpress | 5mg | EUR 181 |
) Liarozole (dihydrochloride) |
|||
| HY-106019C | MedChemExpress | 1mg | EUR 160 |
 Nolatrexed dihydrochloride |
|||
| HY-108474 | MedChemExpress | 10mM/1mL | EUR 138 |
) Dianicline (dihydrochloride) |
|||
| HY-110241 | MedChemExpress | 1mg | EUR 124 |
 Lerociclib dihydrochloride |
|||
| HY-112272A | MedChemExpress | 100mg | EUR 4583 |
) Vatalanib (dihydrochloride) |
|||
| HY-12018 | MedChemExpress | 100mg | EUR 201 |
) AT7867 (dihydrochloride) |
|||
| HY-12059A | MedChemExpress | 100mg | EUR 1413 |
 GSK369796 Dihydrochloride |
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| HY-12082A | MedChemExpress | 100mg | EUR 1566 |
) GSK3368715 (dihydrochloride) |
|||
| HY-128717A | MedChemExpress | 10mM/1mL | EUR 549 |
) Vanoxerine (dihydrochloride) |
|||
| HY-13217 | MedChemExpress | 10mM/1mL | EUR 126 |
) Dorsomorphin (dihydrochloride) |
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| HY-13418 | MedChemExpress | 100mg | EUR 670 |
) PF429242 (dihydrochloride) |
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| HY-13447A | MedChemExpress | 10mM/1mL | EUR 172 |
) Mitoxantrone (dihydrochloride) |
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| HY-13502A | MedChemExpress | 50mg | EUR 119 |
 Cutamesine dihydrochloride |
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| HY-13510 | MedChemExpress | 10mM/1mL | EUR 230 |
) Banoxantrone (dihydrochloride) |
|||
| HY-13562A | MedChemExpress | 10mg | EUR 243 |
) Quinacrine (dihydrochloride) |
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| HY-13735A | MedChemExpress | 500mg | EUR 160 |
 Sardomozide dihydrochloride |
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| HY-13746B | MedChemExpress | 10mM/1mL | EUR 226 |
) Latrepirdine (dihydrochloride) |
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| HY-14537 | MedChemExpress | 10mM/1mL | EUR 113 |
) Inolitazone (dihydrochloride) |
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| HY-14792B | MedChemExpress | 5mg | EUR 544 |
) Bavisant (dihydrochloride) |
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| HY-14880A | MedChemExpress | 5mg | EUR 326 |
) Mirodenafil (dihydrochloride) |
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| HY-14930A | MedChemExpress | 50mg | EUR 2116 |
) SCH79797 (dihydrochloride) |
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| HY-14994 | MedChemExpress | 10mg | EUR 1175 |
 Ipatasertib dihydrochloride |
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| HY-15186A | MedChemExpress | 50mg | EUR 383 |
) GW791343 (dihydrochloride) |
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| HY-15469 | MedChemExpress | 5mg | EUR 147 |
 Merestinib dihydrochloride |
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| HY-15514A | MedChemExpress | 10mg | EUR 354 |
) Mibefradil (dihydrochloride) |
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| HY-15553A | MedChemExpress | 10mg | EUR 259 |
 Ceritinib dihydrochloride |
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| HY-15656A | MedChemExpress | 5mg | EUR 108 |
 CRT0066101 dihydrochloride |
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| HY-15698A | MedChemExpress | 25mg | EUR 463 |
 Flupentixol dihydrochloride |
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| HY-15856B | MedChemExpress | 10mg | EUR 131 |
) TMB (dihydrochloride) |
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| HY-15930A | MedChemExpress | 10mM/1mL | EUR 113 |
) Eravacycline (dihydrochloride) |
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| HY-16980A | MedChemExpress | 10mM/1mL | EUR 146 |
) Pirenzepine (dihydrochloride) |
|||
| HY-17037 | MedChemExpress | 500mg | EUR 160 |
) Cetirizine (dihydrochloride) |
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| HY-17042A | MedChemExpress | 10mM/1mL | EUR 126 |
) Pramipexole (dihydrochloride) |
|||
| HY-17355 | MedChemExpress | 10mg | EUR 119 |
) Dexpramipexole (dihydrochloride) |
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| HY-17355A | MedChemExpress | 10mg | EUR 153 |
) Ranolazine (dihydrochloride) |
|||
| HY-17401 | MedChemExpress | 10mM/1mL | EUR 156 |
) Manidipine (dihydrochloride) |
|||
| HY-17403 | MedChemExpress | 10mM/1mL | EUR 134 |
) Prexasertib (dihydrochloride) |
|||
| HY-18174A | MedChemExpress | 100mg | EUR 1083 |
) Azimilide (Dihydrochloride) |
|||
| HY-18600A | MedChemExpress | 100mg | EUR 1083 |
) 1400W (Dihydrochloride) |
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| HY-18731 | MedChemExpress | 10mM/1mL | EUR 126 |
) MS023 (dihydrochloride) |
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| HY-19615B | MedChemExpress | 100mg | EUR 911 |
) DG172 (dihydrochloride) |
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| HY-19737A | MedChemExpress | 50mg | EUR 587 |
) Elacestrant (dihydrochloride) |
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| HY-19822A | MedChemExpress | 10mM/1mL | EUR 613 |
 Talipexole dihydrochloride |
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| HY-A0008 | MedChemExpress | 10mM/1mL | EUR 179 |
) Decloxizine (dihydrochloride) |
|||
| HY-A0075 | MedChemExpress | 100mg | EUR 243 |
) Fluphenazine (dihydrochloride) |
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| HY-A0081 | MedChemExpress | 100mg | EUR 133 |
) Sapropterin (dihydrochloride) |
|||
| HY-A0124A | MedChemExpress | 100mg | EUR 243 |
Integrative evaluation of advanced most cancers genomics and medical profiles utilizing the cBioPortal.
- The cBioPortal for Most cancers Genomics (http://cbioportal.org) supplies a Internet useful resource for exploring, visualizing, and analyzing multidimensional most cancers genomics knowledge. The portal reduces molecular profiling knowledge from most cancers tissues and cell strains into readily comprehensible genetic, epigenetic, gene expression, and proteomic occasions.
- The question interface mixed with custom-made knowledge storage allows researchers to interactively discover genetic alterations throughout samples, genes, and pathways and, when out there within the underlying knowledge, to hyperlink these to medical outcomes. The portal supplies graphical summaries of gene-level knowledge from a number of platforms, community visualization and evaluation, survival evaluation, patient-centric queries, and software program programmatic entry.
ERLOTINIB, HYDROCHLORIDE SALT, >99%
- The intuitive Internet interface of the portal makes advanced most cancers genomics profiles accessible to researchers and clinicians with out requiring bioinformatics experience, thus facilitating organic discoveries. Right here, we offer a sensible information to the evaluation and visualization options of the cBioPortal for Most cancers Genomics.
BACKGROUND
Earlier, uncontrolled research have suggested that first-line remedy with gefitinib would be efficacious in chosen sufferers with non-small-cell lung most cancers.
METHODS
On this section 3, open-label research, we randomly assigned beforehand untreated sufferers in East Asia who had superior pulmonary adenocarcinoma and who had been nonsmokers or former mild people who smoke to obtain gefitinib (250 mg per day) (609 sufferers) or carboplatin (at a dose calculated to provide an space beneath the curve of 5 or 6 mg per milliliter per minute) plus paclitaxel (200 mg per sq. meter of body-surface space) (608 sufferers). The first finish level was progression-free survival.
) Palbociclib (hydrochloride) |
|||
| HY-50767A | MedChemExpress | 200mg | EUR 243 |
 Palbociclib |
|||
| HY-50767 | MedChemExpress | 1g | EUR 623 |
 Erlotinib, Hydrochloride Salt |
|||
| 1588-100 | Biovision | EUR 169 | |
Erlotinib, Hydrochloride Salt |
|||
| 1588-1000 | Biovision | EUR 398 | |
) Palbociclib (isethionate) |
|||
| HY-A0065 | MedChemExpress | 200mg | EUR 271 |
 Erlotinib, Hydrochloride Salt, >99% |
|||
| BC026-101 | GenDepot | 1g | EUR 273 |
Erlotinib, Hydrochloride Salt, >99% |
|||
| BC026-102 | GenDepot | 2g | EUR 388 |
Erlotinib, Hydrochloride Salt, >99% |
|||
| BC026-105 | GenDepot | 5g | EUR 570 |
) PD 0332991 (Palbociclib) |
|||
| B7798-25 | ApexBio | 25 mg | EUR 154 |
PD 0332991 (Palbociclib) |
|||
| B7798-5 | ApexBio | 5 mg | EUR 108 |
PD 0332991 (Palbociclib) |
|||
| B7798-S | ApexBio | Evaluation Sample | EUR 81 |
 Isethionate) Palbociclib (PD0332991) Isethionate |
|||
| A8335-10 | ApexBio | 10 mg | EUR 142 |
Palbociclib (PD0332991) Isethionate |
|||
| A8335-25 | ApexBio | 25 mg | EUR 224 |
Palbociclib (PD0332991) Isethionate |
|||
| A8335-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 131 |
Palbociclib (PD0332991) Isethionate |
|||
| A8335-50 | ApexBio | 50 mg | EUR 316 |
Palbociclib (PD0332991) Isethionate |
|||
| A8335-S | ApexBio | Evaluation Sample | EUR 81 |
 17-DMAG, Hydrochloride Salt, >98% |
|||
| BC024-001 | GenDepot | 1mg | EUR 178 |
17-DMAG, Hydrochloride Salt, >98% |
|||
| BC024-005 | GenDepot | 5mg | EUR 286 |
17-DMAG, Hydrochloride Salt, >98% |
|||
| BC024-010 | GenDepot | 10mg | EUR 408 |
17-DMAG, Hydrochloride Salt, >98% |
|||
| BC024-025 | GenDepot | 25mg | Ask for price |
 17-DMAG, Hydrochloride Salt, >99% |
|||
| BC024-100 | GenDepot | 100mg | Ask for price |
17-DMAG, Hydrochloride Salt, >99% |
|||
| BC024-101 | GenDepot | 1g | Ask for price |
17-DMAG, Hydrochloride Salt, >99% |
|||
| BC024-250 | GenDepot | 250mg | Ask for price |
 OSU-03012, Hydrochloride Salt, >98% |
|||
| BC061-005 | GenDepot | 5mg | EUR 313 |
OSU-03012, Hydrochloride Salt, >98% |
|||
| BC061-025 | GenDepot | 25mg | EUR 529 |
 HCl) PD 0332991 (Palbociclib) HCl |
|||
| A8316-25 | ApexBio | 25 mg | EUR 154 |
PD 0332991 (Palbociclib) HCl |
|||
| A8316-5 | ApexBio | 5 mg | EUR 108 |
PD 0332991 (Palbociclib) HCl |
|||
| A8316-S | ApexBio | Evaluation Sample | EUR 81 |
 Bile salt |
|||
| BB0225 | Bio Basic | 25g | EUR 79.58 |
) Laurolitsine (hydrochloride) |
|||
| HY-N2352A | MedChemExpress | 10mg | EUR 1318 |
) Tirzepatide (hydrochloride) |
|||
| HY-P1731B | MedChemExpress | 5mg | EUR 1427 |
) Etelcalcetide (hydrochloride) |
|||
| HY-P1955A | MedChemExpress | 10mg | EUR 349 |
) Piridocaine (hydrochloride) |
|||
| HY-U00109 | MedChemExpress | 10mg | EUR 986 |
) Cyclodrine (hydrochloride) |
|||
| HY-U00139 | MedChemExpress | 5mg | EUR 601 |
) Drobuline (hydrochloride) |
|||
| HY-U00149 | MedChemExpress | 5mg | EUR 877 |
 Dopexamine hydrochloride |
|||
| HY-U00205 | MedChemExpress | 1mg | EUR 463 |
 AE0047 Hydrochloride |
|||
| HY-U00284 | MedChemExpress | 20mg | EUR 3356 |
 Bometolol Hydrochloride |
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| HY-U00386 | MedChemExpress | 1mg | EUR 3218 |
 GSK2850163 hydrochloride |
|||
| HY-U00459B | MedChemExpress | 10mg | EUR 371 |
) TCEP (hydrochloride) |
|||
| HY-W011500 | MedChemExpress | 10mM/1mL | EUR 113 |
) Tulobuterol (hydrochloride) |
|||
| HY-W011733 | MedChemExpress | 500mg | EUR 199 |
 MCLA hydrochloride |
|||
| HY-W013275 | MedChemExpress | 5mg | EUR 318 |
 Icotinib hydrochloride |
|||
| I035-10MG | TOKU-E | 10 mg | EUR 347 |
 Kasugamycin hydrochloride |
|||
| K005-10G | TOKU-E | 10 g | EUR 276 |
Kasugamycin hydrochloride |
|||
| K005-1G | TOKU-E | 1 g | EUR 86 |
Kasugamycin hydrochloride |
|||
| K005-50G | TOKU-E | 50 g | EUR 868 |
 Methacycline hydrochloride |
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| M003-100MG | TOKU-E | 100 mg | EUR 139 |
Methacycline hydrochloride |
|||
| M003-1G | TOKU-E | 1 g | EUR 187 |
 Minocycline hydrochloride |
|||
| M008-1G | TOKU-E | 1 g | EUR 347 |
Minocycline hydrochloride |
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| M008-500MG | TOKU-E | 500 mg | EUR 200 |
 Mitoxantrone hydrochloride |
|||
| M010-50MG | TOKU-E | 50 mg | EUR 129 |
 Lomefloxacin hydrochloride |
|||
| L005-1G | TOKU-E | 1 g | EUR 74 |
Lomefloxacin hydrochloride |
|||
| L005-5G | TOKU-E | 5 g | EUR 153 |
 Daunorubicin hydrochloride |
|||
| D001-10MG | TOKU-E | 10 mg | EUR 119 |
Daunorubicin hydrochloride |
|||
| D001-50MG | TOKU-E | 50 mg | EUR 400 |
 Difloxacin hydrochloride |
|||
| D021-1G | TOKU-E | 1 g | EUR 111 |
Difloxacin hydrochloride |
|||
| D021-5G | TOKU-E | 5 g | EUR 365 |
 Demeclocycline hydrochloride |
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| D032-1G | TOKU-E | 1 g | EUR 174 |
Demeclocycline hydrochloride |
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| D032-250MG | TOKU-E | 250 mg | EUR 88 |
Demeclocycline hydrochloride |
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| D032-5G | TOKU-E | 5 g | EUR 539 |
 Doxycycline Hydrochloride |
|||
| D065-25MG | TOKU-E | 25mg | EUR 342 |
Doxycycline Hydrochloride |
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| D065-5MG | TOKU-E | 5mg | EUR 119 |
 Dalbavancin Hydrochloride |
|||
| D092-10MG | TOKU-E | 10mg | EUR 127 |
Dalbavancin Hydrochloride |
|||
| D092-50MG | TOKU-E | 50mg | EUR 380 |
 Dimethylamine hydrochloride |
|||
| DB0410 | Bio Basic | 500g | EUR 96.98 |
 Betaine hydrochloride |
|||
| BB0133 | Bio Basic | 250g | EUR 75.52 |
 Benzamidine hydrochloride |
|||
| BD0076 | Bio Basic | 25g | EUR 81.32 |
 Cefepime Hydrochloride |
|||
| C009-100MG | TOKU-E | 100 mg | EUR 267 |
 Ceftazidime Hydrochloride |
|||
| C020-1G | TOKU-E | 1 g | EUR 622 |
 Ciprofloxacin hydrochloride |
|||
| C032-25G | TOKU-E | 25 g | EUR 166 |
Ciprofloxacin hydrochloride |
|||
| C032-5G | TOKU-E | 5 g | EUR 62 |
 Clindamycin Hydrochloride |
|||
| C035-100MG | TOKU-E | 100 mg | EUR 203 |
Clindamycin Hydrochloride |
|||
| C035-50MG | TOKU-E | 50 mg | EUR 127 |
 Chlortetracycline Hydrochloride |
|||
| C072-100G | TOKU-E | 100 g | EUR 314 |
Chlortetracycline Hydrochloride |
|||
| C072-25G | TOKU-E | 25 g | EUR 131 |
Chlortetracycline Hydrochloride |
|||
| C072-5G | TOKU-E | 5 g | EUR 65 |
 Cefozopran Hydrochloride |
|||
| C099-100MG | TOKU-E | 100 mg | EUR 250 |
 Cysteamine hydrochloride |
|||
| C212-25G | TOKU-E | 25 g | EUR 65 |
Cysteamine hydrochloride |
|||
| C212-4x25G | TOKU-E | 4 x 25 g | EUR 129 |
 Ceftiofur Hydrochloride |
|||
| C228-1G | TOKU-E | 1 g | EUR 108 |
Ceftiofur Hydrochloride |
|||
| C228-5G | TOKU-E | 5 g | EUR 323 |
 Cefmenoxime Hydrochloride |
|||
| C240-100MG | TOKU-E | 100mg | EUR 114 |
Cefmenoxime Hydrochloride |
|||
| C240-500MG | TOKU-E | 500mg | EUR 279 |
 Cinacalcet Hydrochloride |
|||
| C242-100MG | TOKU-E | 100mg | EUR 428 |
Cinacalcet Hydrochloride |
|||
| C242-10MG | TOKU-E | 10mg | EUR 79 |
) Flavopiridol (Hydrochloride) |
|||
| HY-10006 | MedChemExpress | 10mM/1mL | EUR 126 |
 PRX933 hydrochloride |
|||
| HY-100171 | MedChemExpress | 10mg | EUR 2258 |
) Varenicline (Hydrochloride) |
|||
| HY-10020 | MedChemExpress | 100mg | EUR 739 |
RESULTS
The 12-month charges of progression-free survival had been 24.9% with gefitinib and 6.7% with carboplatin-paclitaxel. The research met its major goal of displaying the noninferiority of gefitinib and in addition confirmed its superiority, as in contrast with carboplatin-paclitaxel, with respect to progression-free survival within the intention-to-treat inhabitants (hazard ratio for development or dying, 0.74; 95% confidence interval [CI], 0.65 to 0.85; P<0.001).
PALBOCICLIB (PD0332991) ISETHIONATE
Within the subgroup of 261 sufferers who had been optimistic for the epidermal progress issue receptor gene (EGFR) mutation, progression-free survival was considerably longer amongst those that acquired gefitinib than amongst those that acquired carboplatin-paclitaxel (hazard ratio for development or dying, 0.48; 95% CI, 0.36 to 0.64; P<0.001), whereas within the subgroup of 176 sufferers who had been detrimental for the mutation, progression-free survival was considerably longer amongst those that acquired carboplatin-paclitaxel (hazard ratio for progression or dying with gefitinib, 2.85; 95% CI, 2.05 to three.98; P<0.001).
The most typical hostile occasions had been rash or pimples (in 66.2% of sufferers) and diarrhea (46.6%) within the gefitinib group and neurotoxic results (69.9%), neutropenia (67.1%), and alopecia (58.4%) within the carboplatin-paclitaxel group.
CONCLUSIONS
Gefitinib is superior to carboplatin-paclitaxel as an preliminary remedy for pulmonary adenocarcinoma amongst nonsmokers or former mild people who smoke in East Asia. The presence in the tumor of a mutation of the EGFR gene is a robust predictor of a greater consequence with gefitinib. (ClinicalTrials.gov quantity, NCT00322452.)
