Inhabitants pharmacokinetics of colistin methanesulfonate and shaped colistin in critically sick sufferers from a multicenter examine present dosing solutions for varied classes of sufferers.
- With growing medical emergence of multidrug-resistant Gram-negative pathogens and the paucity of recent brokers to fight these infections, colistin (administered as its inactive prodrug colistin methanesulfonate [CMS]) has reemerged as a remedy choice, particularly for critically sick sufferers.
- There was a dearth of pharmacokinetic (PK) knowledge obtainable to guide dosing in critically sick sufferers, together with these on renal alternative remedy.
HYDROXYSTILBAMIDINE BIS(METHANESULFONATE)
- In an ongoing examine to develop a inhabitants PK mannequin for CMS and colistin, 105 sufferers have been studied so far; these included 12 sufferers on hemodialysis and four on steady renal replacement remedy. For patients not on renal alternative, there was a large variance in creatinine clearance, starting from three to 169 ml/min/1.73 m(2). Every affected person was handled with a physician-selected CMS dosage routine, and eight blood samples for PK evaluation have been collected throughout a dosage interval on day three or four of remedy.
- A linear PK mannequin with two compartments for CMS and one compartment for shaped colistin greatest described the info. Covariates included creatinine clearance on the entire clearance of CMS and colistin, in addition to physique weight on the central quantity of CMS. Mannequin-fitted parameter estimates have been used to derive instructed loading and upkeep dosing regimens for varied classes of sufferers, together with these on hemodialysis and steady renal alternative.
IMATINIB, METHANESULFONATE SALT, >99%
- Primarily based on our present understanding of colistin POkay and pharmacodynamic relationships, colistin could greatest be used as a part of a extremely lively mixture, particularly for sufferers with average to good renal perform and/or for organisms with MICs of ≥ 1.Zero mg/liter.
![]() Imatinib, Methanesulfonate Salt, >99% |
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BC040-101 | GenDepot | 1g | EUR 232 |
![]() Imatinib, Methanesulfonate Salt, >99% |
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BC040-102 | GenDepot | 2g | EUR 300 |
![]() Imatinib, Methanesulfonate Salt, >99% |
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BC040-105 | GenDepot | 5g | EUR 421 |
![]() Imatinib, Methanesulfonate Salt, >99% |
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BC040-500 | GenDepot | 500mg | Ask for price |
![]() Colistin Methanesulfonate (sodium salt) |
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C3046-1000 | ApexBio | 1 g | EUR 174 |
![]() Colistin Methanesulfonate (sodium salt) |
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C3046-5000 | ApexBio | 5 g | EUR 612 |
![]() Dabrafenib |
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D072-10MG | TOKU-E | 10 mg | EUR 133 |
![]() Dabrafenib |
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D072-25MG | TOKU-E | 25 mg | EUR 222 |
![]() Dabrafenib |
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HY-14660 | MedChemExpress | 100mg | EUR 211 |
![]() Dabrafenib |
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20-abx182412 | Abbexa |
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![]() Dabrafenib (Mesylate) |
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HY-14660A | MedChemExpress | 10mM/1mL | EUR 128 |
![]() Dabrafenib (GSK2118436) |
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B1407-10 | ApexBio | 10 mg | EUR 131 |
![]() Dabrafenib (GSK2118436) |
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B1407-100 | ApexBio | 100 mg | EUR 328 |
![]() Dabrafenib (GSK2118436) |
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B1407-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 113 |
![]() Dabrafenib (GSK2118436) |
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B1407-50 | ApexBio | 50 mg | EUR 224 |
![]() Abemaciclib (methanesulfonate) |
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HY-16297 | MedChemExpress | 500mg | EUR 452 |
![]() Ethyl methanesulfonate |
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20-abx186442 | Abbexa |
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![]() Tricaine methanesulfonate |
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GE5936-10G | Glentham Life Sciences | 10 g | EUR 57 |
![]() Tricaine methanesulfonate |
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GE5936-25G | Glentham Life Sciences | 25 g | EUR 82 |
![]() Tricaine methanesulfonate |
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GE5936-50G | Glentham Life Sciences | 50 g | EUR 118 |
![]() Tricaine methanesulfonate |
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GE5936-5G | Glentham Life Sciences | 5 g | EUR 47 |
![]() Ethyl methanesulfonate |
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GX0446-100G | Glentham Life Sciences | 100 g | EUR 261 |
![]() Ethyl methanesulfonate |
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GX0446-10G | Glentham Life Sciences | 10 g | EUR 74 |
![]() Ethyl methanesulfonate |
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GX0446-25G | Glentham Life Sciences | 25 g | EUR 118 |
![]() Ethyl methanesulfonate |
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GX0446-5G | Glentham Life Sciences | 5 g | EUR 54 |
![]() Silver methanesulfonate |
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GX5020-25G | Glentham Life Sciences | 25 g | EUR 174 |
![]() Silver methanesulfonate |
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GX5020-5G | Glentham Life Sciences | 5 g | EUR 71 |
![]() Pridinol Methanesulfonate |
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A8507-1000 | ApexBio | 1 g | EUR 431 |
![]() Pridinol Methanesulfonate |
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A8507-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 108 |
![]() Pridinol Methanesulfonate |
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A8507-50 | ApexBio | 50 mg | EUR 128 |
![]() Pridinol Methanesulfonate |
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A8507-5000 | ApexBio | 5 g | EUR 999 |
![]() Dabrafenib Mesylate (GSK-2118436) |
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A3347-10 | ApexBio | 10 mg | EUR 131 |
![]() Dabrafenib Mesylate (GSK-2118436) |
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A3347-100 | ApexBio | 100 mg | EUR 328 |
![]() Dabrafenib Mesylate (GSK-2118436) |
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A3347-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 125 |
![]() Dabrafenib Mesylate (GSK-2118436) |
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A3347-50 | ApexBio | 50 mg | EUR 224 |
![]() Dabrafenib Mesylate (GSK-2118436) |
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A3347-S | ApexBio | Evaluation Sample | EUR 81 |
![]() Colistin Sodium Methanesulfonate |
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C073-10G | TOKU-E | 10 g | EUR 820 |
![]() Colistin Sodium Methanesulfonate |
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C073-1G | TOKU-E | 1 g | EUR 135 |
![]() Colistin Sodium Methanesulfonate |
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C073-5G | TOKU-E | 5 g | EUR 440 |
![]() Tariquidar (methanesulfonate, hydrate) |
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HY-10550A | MedChemExpress | 100mg | EUR 612 |
![]() Hydroxystilbamidine bis(methanesulfonate) |
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HY-108166A | MedChemExpress | 5mg | EUR 533 |
![]() PF-06424439 (methanesulfonate) |
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HY-108341A | MedChemExpress | 10mM/1mL | EUR 146 |
![]() PF-04217903 (methanesulfonate) |
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HY-12017A | MedChemExpress | 10mM/1mL | EUR 156 |
![]() BCX 1470 (methanesulfonate) |
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HY-50875 | MedChemExpress | 10mM/1mL | EUR 580 |
![]() 2-Chloroethyl methanesulfonate |
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20-abx183170 | Abbexa |
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![]() Colistin sodium methanesulfonate |
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GA2961-1G | Glentham Life Sciences | 1 g | EUR 126 |
![]() Colistin sodium methanesulfonate |
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GA2961-5G | Glentham Life Sciences | 5 g | EUR 293 |
![]() PF-04217903 methanesulfonate |
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A3712-100 | ApexBio | 100 mg | EUR 595 |
![]() PF-04217903 methanesulfonate |
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A3712-25 | ApexBio | 25 mg | EUR 293 |
![]() PF-04217903 methanesulfonate |
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A3712-5 | ApexBio | 5 mg | EUR 131 |
![]() Tariquidar methanesulfonate, hydrate |
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A3859-10 | ApexBio | 10 mg | EUR 189 |
![]() Tariquidar methanesulfonate, hydrate |
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A3859-50 | ApexBio | 50 mg | EUR 444 |
![]() Ethyl 3-Aminobenzoate (methanesulfonate) |
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C3619-25000 | ApexBio | 25 g | EUR 128 |
![]() Ethyl 3-Aminobenzoate (methanesulfonate) |
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C3619-50000 | ApexBio | 50 g | EUR 195 |
![]() Ethyl 3-Aminobenzoate (methanesulfonate) |
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C3619-100000 | ApexBio | 100 g | EUR 318 |
![]() Ethyl 3-Aminobenzoate (methanesulfonate) |
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C3619-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 113 |
![]() Ro 31-8220 methanesulfonate |
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1946-1 | Biovision | EUR 137 |
![]() Ro 31-8220 methanesulfonate |
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1946-5 | Biovision | EUR 381 |
![]() Bile salt |
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BB0225 | Bio Basic | 25g | EUR 79.58 |
![]() Mupirocin lithium salt |
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M023-100MG | TOKU-E | 100 mg | EUR 380 |
![]() Mupirocin lithium salt |
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M023-500MG | TOKU-E | 500 mg | EUR 762 |
![]() Fluorescein, disodium salt |
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FB0203 | Bio Basic | 100g | EUR 63.92 |
![]() Diethylcarbamazine citrate salt |
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D079-1G | TOKU-E | 1 g | EUR 49 |
![]() Diethylcarbamazine citrate salt |
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D079-5x1G | TOKU-E | 5 x 1 g | EUR 118 |
![]() DIPSO monosodium salt |
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DB0422 | Bio Basic | 50g | EUR 83.06 |
![]() Dimethylglyoxime disodium salt |
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DD1221 | Bio Basic | 100g | EUR 63.92 |
![]() BCIP toluidine salt |
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BB0072 | Bio Basic | 500mg | EUR 134.39 |
![]() BES, monosodium salt |
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BB0131 | Bio Basic | 25g | EUR 67.4 |
![]() BCIP disodium salt |
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BB1171 | Bio Basic | 500mg | EUR 232.7 |
![]() Cefamandole sodium salt |
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C079-100MG | TOKU-E | 100 mg | EUR 148 |
![]() Cefamandole sodium salt |
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C079-500MG | TOKU-E | 500 mg | EUR 474 |
![]() Chlorhexidine diacetate salt |
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C200-25G | TOKU-E | 25 g | EUR 180 |
![]() Methoxatin (disodium salt) |
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HY-100196A | MedChemExpress | 10mM/1mL | EUR 186 |
![]() Nigericin (sodium salt) |
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HY-100381 | MedChemExpress | 100mg | EUR 725 |
Heteroresistance to colistin in multidrug-resistant Acinetobacter baumannii.
- Multidrug-resistant Acinetobacter baumannii has emerged as a major medical downside worldwide and colistin is getting used more and more as “salvage” remedy. MICs of colistin towards A. baumannii point out its vital exercise. Nonetheless, resistance to colistin in A. baumannii has been reported just lately. Clonotypes of 16 medical A.
Creatine phosphate, disodium salt, Tetrahydrate
- baumannii isolates and ATCC 19606 have been decided by pulsed-field gel electrophoresis (PFGE), and colistin MICs have been measured. The time-kill kinetics of colistin towards A. baumannii ATCC 19606 and medical isolate 6 have been investigated, and inhabitants evaluation profiles (PAPs) have been performed. Resistance growth was investigated by serial passaging with or with out publicity to colistin.
- 5 completely different PFGE banding patterns have been discovered within the medical isolates. MICs of colistin towards all isolates have been inside 0.25 to 2 microg/ml. Colistin confirmed early concentration-dependent killing, however bacterial regrowth was noticed at 24 h. PAPs revealed that heteroresistance to colistin occurred in 15 of the 16 medical isolates. Subpopulations (<0.1% from inocula of 10(8) to 10(9) CFU/ml) of ATCC 19606, and most medical isolates grew within the presence of colistin three to 10 microg/ml.
Check- IPL Match Prediction 2021
![]() Ruxolitinib . phosphate salt |
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10-043 | ProSci | 25 mg | EUR 323.3 |
![]() Ruxolitinib (phosphate) |
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HY-50858 | MedChemExpress | 5mg | EUR 119 |
![]() Ruxolitinib phosphate |
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A3781-100 | ApexBio | 100 mg | EUR 374 |
![]() Ruxolitinib phosphate |
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A3781-25 | ApexBio | 25 mg | EUR 224 |
![]() Ruxolitinib phosphate |
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A3781-5 | ApexBio | 5 mg | EUR 131 |
![]() Ruxolitinib phosphate |
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A3781-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 113 |
![]() Ruxolitinib |
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HY-50856 | MedChemExpress | 10mM/1mL | EUR 141 |
![]() Ruxolitinib |
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20-abx076799 | Abbexa |
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![]() Dexamethasone phosphate . disodium salt |
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21-804 | ProSci | 5 g | EUR 398.9 |
![]() Ruxolitinib (sulfate) |
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HY-50859 | MedChemExpress | 100mg | EUR 519 |
![]() INCB018424 (Ruxolitinib) |
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E1KS1378 | EnoGene | 5mg | EUR 521 |
![]() Ruxolitinib (INCB018424) |
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A3012-100 | ApexBio | 100 mg | EUR 374 |
![]() Ruxolitinib (INCB018424) |
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A3012-25 | ApexBio | 25 mg | EUR 224 |
![]() Ruxolitinib (INCB018424) |
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A3012-5 | ApexBio | 5 mg | EUR 131 |
![]() Ruxolitinib (INCB018424) |
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A3012-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 131 |
![]() Ruxolitinib (INCB018424) |
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A3012-S | ApexBio | Evaluation Sample | EUR 81 |
![]() EZSolution? Ruxolitinib |
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B2477-5 | Biovision | EUR 218 |
![]() Galactose 1-phosphate Potassium salt |
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HY-113143A | MedChemExpress | 50mg | EUR 165 |
![]() Creatine phosphate, disodium salt, Tetrahydrate |
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CB0128 | Bio Basic | 5g | EUR 70.88 |
![]() 4-Methylumbelliferyl phosphate disodium salt |
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GC5745-1G | Glentham Life Sciences | 1 g | EUR 166 |
![]() 4-Methylumbelliferyl phosphate disodium salt |
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GC5745-250MG | Glentham Life Sciences | 250 mg | EUR 75 |
![]() beta-Cyclodextrin phosphate sodium salt |
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GC6118-100MG | Glentham Life Sciences | 100 mg | EUR 142 |
![]() beta-Cyclodextrin phosphate sodium salt |
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GC6118-250MG | Glentham Life Sciences | 250 mg | EUR 220 |
![]() Phenyl phosphate disodium salt dihydrate |
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GE1672-100G | Glentham Life Sciences | 100 g | EUR 150 |
![]() Phenyl phosphate disodium salt dihydrate |
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GE1672-10G | Glentham Life Sciences | 10 g | EUR 52 |
![]() Phenyl phosphate disodium salt dihydrate |
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GE1672-25G | Glentham Life Sciences | 25 g | EUR 74 |
![]() Phenyl phosphate disodium salt dihydrate |
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GE1672-50G | Glentham Life Sciences | 50 g | EUR 99 |
![]() Creatine phosphate disodium salt hydrate |
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GE7721-100G | Glentham Life Sciences | 100 g | EUR 333 |
![]() Creatine phosphate disodium salt hydrate |
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GE7721-25G | Glentham Life Sciences | 25 g | EUR 150 |
![]() Creatine phosphate disodium salt hydrate |
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GE7721-5G | Glentham Life Sciences | 5 g | EUR 74 |
![]() Dexamethasone 21-phosphate disodium salt |
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GL6086-1G | Glentham Life Sciences | 1 g | EUR 110 |
![]() Dexamethasone 21-phosphate disodium salt |
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GL6086-5G | Glentham Life Sciences | 5 g | EUR 269 |
![]() Ruxolitinib (S enantiomer) |
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HY-50856A | MedChemExpress | 5mg | EUR 340 |
![]() S-Ruxolitinib (INCB018424) |
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A4149-1 | ApexBio | 1 mg | EUR 231 |
![]() S-Ruxolitinib (INCB018424) |
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A4149-5 | ApexBio | 5 mg | EUR 429 |
![]() S-Ruxolitinib (INCB018424) |
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A4149-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 306 |
![]() Ruxolitinib, Free base |
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2139-100 | Biovision | Ask for price |
![]() Ruxolitinib, Free base |
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2139-25 | Biovision | EUR 533 |
![]() Ruxolitinib, Free base |
|||
2139-5 | Biovision | EUR 207 |
![]() Ruxolitinib (free base) |
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10-042 | ProSci | 25 mg | EUR 348.5 |
![]() 4-Nitrophenyl phosphate disodium salt hexahydrate |
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CSUB-0027 | Creative Enzymes | 4g | EUR 270 |
![]() Glucose-6-phosphate, disodium salt, hydrate |
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GB0481 | Bio Basic | 1g | EUR 74.36 |
![]() β-Glycerol phosphate (disodium salt pentahydrate) |
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HY-D0886 | MedChemExpress | 500mg | EUR 108 |
![]() D-Glucose-6-phosphate disodium salt |
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20-abx180718 | Abbexa |
|
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![]() 1-Naphthyl phosphate disodium salt hydrate |
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GE8832-1G | Glentham Life Sciences | 1 g | EUR 86 |
![]() 1-Naphthyl phosphate disodium salt hydrate |
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GE8832-25G | Glentham Life Sciences | 25 g | EUR 485 |
![]() 1-Naphthyl phosphate disodium salt hydrate |
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GE8832-5G | Glentham Life Sciences | 5 g | EUR 174 |
![]() beta-Glycerol phosphate disodium salt pentahydrate |
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GK9068-25G | Glentham Life Sciences | 25 g | EUR 54 |
![]() D-Glucose-6-phosphate monosodium salt |
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GC0472-1G | Glentham Life Sciences | 1 g | EUR 126 |
![]() D-Glucose-6-phosphate monosodium salt |
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GC0472-500MG | Glentham Life Sciences | 500 mg | EUR 81 |
![]() D-Fructose-6-phosphate disodium salt |
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GC1944-1G | Glentham Life Sciences | 1 g | EUR 146 |
![]() 4-Nitrophenyl phosphate disodium salt hexahydrate |
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GC2733-25G | Glentham Life Sciences | 25 g | EUR 102 |
![]() 4-Nitrophenyl phosphate disodium salt hexahydrate |
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GC2733-5G | Glentham Life Sciences | 5 g | EUR 62 |
![]() Glycerol-1-phosphate magnesium salt hydrate |
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GC3404-100G | Glentham Life Sciences | 100 g | EUR 70 |
![]() Glycerol-1-phosphate magnesium salt hydrate |
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GC3404-1KG | Glentham Life Sciences | 1 kg | EUR 269 |
![]() Glycerol-1-phosphate magnesium salt hydrate |
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GC3404-250G | Glentham Life Sciences | 250 g | EUR 110 |
![]() Glycerol-1-phosphate magnesium salt hydrate |
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GC3404-500G | Glentham Life Sciences | 500 g | EUR 170 |
![]() Glycerol phosphate disodium salt hydrate, 99% |
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GC7456-100G | Glentham Life Sciences | 100 g | EUR 66 |
![]() Glycerol phosphate disodium salt hydrate, 99% |
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GC7456-1KG | Glentham Life Sciences | 1 kg | EUR 213 |
![]() Glycerol phosphate disodium salt hydrate, 99% |
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GC7456-250G | Glentham Life Sciences | 250 g | EUR 94 |
![]() Glycerol phosphate disodium salt hydrate, 99% |
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GC7456-25G | Glentham Life Sciences | 25 g | EUR 46 |
![]() Glycerol phosphate disodium salt hydrate, 99% |
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GC7456-500G | Glentham Life Sciences | 500 g | EUR 142 |
![]() D-Glucose-6-phosphate disodium salt |
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GC9849-10MG | Glentham Life Sciences | 10 mg | EUR 42 |
![]() D-Glucose-6-phosphate disodium salt |
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GC9849-1G | Glentham Life Sciences | 1 g | EUR 62 |
![]() D-Glucose-6-phosphate disodium salt |
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GC9849-500MG | Glentham Life Sciences | 500 mg | EUR 54 |
![]() 1-Naphthyl phosphate monosodium salt hydrate |
|||
GE3933-1G | Glentham Life Sciences | 1 g | EUR 52 |
![]() 1-Naphthyl phosphate monosodium salt hydrate |
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GE3933-5G | Glentham Life Sciences | 5 g | EUR 102 |
![]() D-Glucose-6-phosphate disodium salt |
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GC9849-25G | Glentham Life Sciences | 25 g | EUR 548 |
![]() D-Glucose-6-phosphate disodium salt |
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GC9849-5G | Glentham Life Sciences | 5 g | EUR 174 |
![]() 1-Naphthyl phosphate monosodium salt hydrate |
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GE3933-10G | Glentham Life Sciences | 10 g | EUR 156 |
![]() 1-Naphthyl phosphate monosodium salt hydrate |
|||
GE3933-25G | Glentham Life Sciences | 25 g | EUR 285 |
![]() Riboflavin-5-phosphate, sodium salt, dihydrate |
|||
RD0472 | Bio Basic | 25g | EUR 72.62 |
![]() Riboflavin-5'-phosphate monosodium salt hydrate |
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GP6544-100G | Glentham Life Sciences | 100 g | EUR 190 |
![]() Riboflavin-5'-phosphate monosodium salt hydrate |
|||
GP6544-250G | Glentham Life Sciences | 250 g | EUR 317 |
![]() Riboflavin-5'-phosphate monosodium salt hydrate |
|||
GP6544-25G | Glentham Life Sciences | 25 g | EUR 94 |
![]() Riboflavin-5'-phosphate monosodium salt hydrate |
|||
GP6544-5G | Glentham Life Sciences | 5 g | EUR 58 |
![]() Ruxolitinib (JAK kinase inhibitor) |
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SIH-509-25MG | Stressmarq | 25 mg | EUR 625 |
- 4 successive passages of ATCC 19606 in broth containing colistin (as much as 200 microg/ml) considerably elevated the proportion of the resistant subpopulations capable of develop within the presence of colistin at 10 microg/ml from 0.000023 to 100%; even after 16 passages in colistin-free broth, the proportion solely decreased to 2.1%.
Glucose-6-phosphate, disodium salt, hydrate
- This represents the primary demonstration of straightgeneous colistin-resistant A. baumannii in “colistin-susceptible” medical isolates. Our findings give a powerful warning that colistin-resistant A. baumannii could also be noticed extra ceaselessly resulting from potential suboptimal dosage regimens really useful within the product data of some merchandise of colistin methanesulfonate.