Inhabitants pharmacokinetics of colistin methanesulfonate and shaped colistin in critically sick sufferers from a multicenter examine present dosing solutions for varied classes of sufferers.
- With growing medical emergence of multidrug-resistant Gram-negative pathogens and the paucity of recent brokers to fight these infections, colistin (administered as its inactive prodrug colistin methanesulfonate [CMS]) has reemerged as a remedy choice, particularly for critically sick sufferers.
- There was a dearth of pharmacokinetic (PK) knowledge obtainable to guide dosing in critically sick sufferers, together with these on renal alternative remedy.
HYDROXYSTILBAMIDINE BIS(METHANESULFONATE)
- In an ongoing examine to develop a inhabitants PK mannequin for CMS and colistin, 105 sufferers have been studied so far; these included 12 sufferers on hemodialysis and four on steady renal replacement remedy. For patients not on renal alternative, there was a large variance in creatinine clearance, starting from three to 169 ml/min/1.73 m(2). Every affected person was handled with a physician-selected CMS dosage routine, and eight blood samples for PK evaluation have been collected throughout a dosage interval on day three or four of remedy.
- A linear PK mannequin with two compartments for CMS and one compartment for shaped colistin greatest described the info. Covariates included creatinine clearance on the entire clearance of CMS and colistin, in addition to physique weight on the central quantity of CMS. Mannequin-fitted parameter estimates have been used to derive instructed loading and upkeep dosing regimens for varied classes of sufferers, together with these on hemodialysis and steady renal alternative.
IMATINIB, METHANESULFONATE SALT, >99%
- Primarily based on our present understanding of colistin POkay and pharmacodynamic relationships, colistin could greatest be used as a part of a extremely lively mixture, particularly for sufferers with average to good renal perform and/or for organisms with MICs of ≥ 1.Zero mg/liter.
Imatinib, Methanesulfonate Salt, >99% |
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BC040-101 | GenDepot | 1g | EUR 278.4 |
Imatinib, Methanesulfonate Salt, >99% |
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BC040-102 | GenDepot | 2g | EUR 360 |
Imatinib, Methanesulfonate Salt, >99% |
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BC040-105 | GenDepot | 5g | EUR 505.2 |
Imatinib, Methanesulfonate Salt, >99% |
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BC040-500 | GenDepot | 500mg | Ask for price |
Colistin Methanesulfonate (sodium salt) |
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C3046-1000 | ApexBio | 1 g | EUR 208.8 |
Colistin Methanesulfonate (sodium salt) |
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C3046-5000 | ApexBio | 5 g | EUR 734.4 |
Ethyl methanesulfonate |
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20-abx186442 | Abbexa |
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Ethyl methanesulfonate |
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GX0446-100G | Glentham Life Sciences | 100 g | EUR 313.2 |
Ethyl methanesulfonate |
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GX0446-10G | Glentham Life Sciences | 10 g | EUR 88.8 |
Ethyl methanesulfonate |
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GX0446-25G | Glentham Life Sciences | 25 g | EUR 141.6 |
Ethyl methanesulfonate |
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GX0446-5G | Glentham Life Sciences | 5 g | EUR 64.8 |
Ethyl methanesulfonate |
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S-1930 | Scientific Laboratory Supplies | 1ML | EUR 84 |
Ethyl methanesulfonate |
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GX0446-10 | Glentham Life Sciences | 10 | EUR 43.5 |
Ethyl methanesulfonate |
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GX0446-100 | Glentham Life Sciences | 100 | EUR 229.3 |
Ethyl methanesulfonate |
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GX0446-25 | Glentham Life Sciences | 25 | EUR 87.1 |
Ethyl methanesulfonate |
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GX0446-5 | Glentham Life Sciences | 5 | EUR 23.8 |
BCX 1470 (methanesulfonate) |
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HY-50875 | MedChemExpress | 10mM/1mL | EUR 696 |
Silver methanesulfonate |
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GX5020-25G | Glentham Life Sciences | 25 g | EUR 208.8 |
Silver methanesulfonate |
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GX5020-5G | Glentham Life Sciences | 5 g | EUR 85.2 |
Silver methanesulfonate |
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GX5020-25 | Glentham Life Sciences | 25 | EUR 142.4 |
Silver methanesulfonate |
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GX5020-5 | Glentham Life Sciences | 5 | EUR 40.3 |
Pridinol Methanesulfonate |
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A8507-1000 | ApexBio | 1 g | EUR 517.2 |
Pridinol Methanesulfonate |
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A8507-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 129.6 |
Pridinol Methanesulfonate |
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A8507-50 | ApexBio | 50 mg | EUR 153.6 |
Pridinol Methanesulfonate |
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A8507-5000 | ApexBio | 5 g | EUR 1198.8 |
Tricaine methanesulfonate |
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GE5936-10G | Glentham Life Sciences | 10 g | EUR 68.4 |
Tricaine methanesulfonate |
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GE5936-25G | Glentham Life Sciences | 25 g | EUR 98.4 |
Tricaine methanesulfonate |
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GE5936-50G | Glentham Life Sciences | 50 g | EUR 141.6 |
Tricaine methanesulfonate |
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GE5936-5G | Glentham Life Sciences | 5 g | EUR 56.4 |
Tricaine methanesulfonate |
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GE5936-10 | Glentham Life Sciences | 10 | EUR 26.9 |
Tricaine methanesulfonate |
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GE5936-25 | Glentham Life Sciences | 25 | EUR 51.4 |
Tricaine methanesulfonate |
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GE5936-5 | Glentham Life Sciences | 5 | EUR 16.6 |
Tricaine methanesulfonate |
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GE5936-50 | Glentham Life Sciences | 50 | EUR 87.1 |
Ro 31-8220 methanesulfonate |
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1946-1 | Biovision | each | EUR 164.4 |
Ro 31-8220 methanesulfonate |
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1946-5 | Biovision | each | EUR 457.2 |
Abemaciclib (methanesulfonate) |
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HY-16297 | MedChemExpress | 500mg | EUR 542.4 |
PF-04217903 methanesulfonate |
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A3712-100 | ApexBio | 100 mg | EUR 714 |
PF-04217903 methanesulfonate |
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A3712-25 | ApexBio | 25 mg | EUR 351.6 |
PF-04217903 methanesulfonate |
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A3712-5 | ApexBio | 5 mg | EUR 157.2 |
PF-06424439 (methanesulfonate) |
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HY-108341A | MedChemExpress | 10mM/1mL | EUR 175.2 |
PF-04217903 (methanesulfonate) |
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HY-12017A | MedChemExpress | 10mM/1mL | EUR 187.2 |
2-Chloroethyl methanesulfonate |
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20-abx183170 | Abbexa |
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Colistin Sodium Methanesulfonate |
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C073-10G | TOKU-E | 10 g | EUR 984 |
Colistin Sodium Methanesulfonate |
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C073-1G | TOKU-E | 1 g | EUR 162 |
Colistin Sodium Methanesulfonate |
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C073-5G | TOKU-E | 5 g | EUR 528 |
Colistin sodium methanesulfonate |
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GA2961-1G | Glentham Life Sciences | 1 g | EUR 151.2 |
Colistin sodium methanesulfonate |
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GA2961-5G | Glentham Life Sciences | 5 g | EUR 351.6 |
Colistin sodium methanesulfonate |
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GA2961-1 | Glentham Life Sciences | 1 | EUR 95 |
Colistin sodium methanesulfonate |
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GA2961-5 | Glentham Life Sciences | 5 | EUR 261 |
Tariquidar methanesulfonate, hydrate |
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A3859-10 | ApexBio | 10 mg | EUR 226.8 |
Tariquidar methanesulfonate, hydrate |
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A3859-50 | ApexBio | 50 mg | EUR 532.8 |
Tariquidar (methanesulfonate, hydrate) |
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HY-10550A | MedChemExpress | 100mg | EUR 734.4 |
Hydroxystilbamidine bis(methanesulfonate) |
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HY-108166A | MedChemExpress | 5mg | EUR 639.6 |
Hydroxystilbamidine bis(methanesulfonate) |
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GW9028-10 | Glentham Life Sciences | 10 | EUR 405.4 |
Ethyl 3-Aminobenzoate (methanesulfonate) |
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C3619-100000 | ApexBio | 100 g | EUR 381.6 |
Ethyl 3-Aminobenzoate (methanesulfonate) |
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C3619-25000 | ApexBio | 25 g | EUR 153.6 |
Ethyl 3-Aminobenzoate (methanesulfonate) |
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C3619-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 135.6 |
Ethyl 3-Aminobenzoate (methanesulfonate) |
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C3619-50000 | ApexBio | 50 g | EUR 234 |
Pesticide Std Methyl Methanesulfonate Neat |
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REPET374N | Scientific Laboratory Supplies | 10MG | EUR 91.39 |
Pesticide Std Ethyl methanesulfonate Neat |
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REPET352N | Scientific Laboratory Supplies | 10MG | EUR 91.39 |
Pesticide Std Methyl Methanesulfonate 1000ug/mL in MeOH |
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REPET374 | Scientific Laboratory Supplies | 1ML | EUR 122.73 |
Pesticide Std Methyl Methanesulfonate 2000ug/mL in MeOH |
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REPET375 | Scientific Laboratory Supplies | 1ML | EUR 118.81 |
Pesticide Std Ethyl methanesulfonate 1000ug/mL in MeOH |
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REPET352 | Scientific Laboratory Supplies | 1ML | EUR 110.98 |
Pesticide Std Ethyl methanesulfonate 2000ug/mL in MeOH |
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REPET353 | Scientific Laboratory Supplies | 1ML | EUR 124.03 |
Dabrafenib |
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20-abx182412 | Abbexa |
|
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Dabrafenib |
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D072-10MG | TOKU-E | 10 mg | EUR 159.6 |
Dabrafenib |
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D072-25MG | TOKU-E | 25 mg | EUR 266.4 |
Dabrafenib |
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HY-14660 | MedChemExpress | 100mg | EUR 253.2 |
METHANESULFONIC ACID SODIUM SALT |
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713003 | Survival Technologies | each | Ask for price |
Dabrafenib (Mesylate) |
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HY-14660A | MedChemExpress | 10mM/1mL | EUR 153.6 |
Dabrafenib (GSK2118436) |
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B1407-10 | ApexBio | 10 mg | EUR 157.2 |
Dabrafenib (GSK2118436) |
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B1407-100 | ApexBio | 100 mg | EUR 393.6 |
Dabrafenib (GSK2118436) |
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B1407-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 135.6 |
Dabrafenib (GSK2118436) |
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B1407-50 | ApexBio | 50 mg | EUR 268.8 |
Heteroresistance to colistin in multidrug-resistant Acinetobacter baumannii.
- Multidrug-resistant Acinetobacter baumannii has emerged as a major medical downside worldwide and colistin is getting used more and more as “salvage” remedy. MICs of colistin towards A. baumannii point out its vital exercise. Nonetheless, resistance to colistin in A. baumannii has been reported just lately. Clonotypes of 16 medical A.
Creatine phosphate, disodium salt, Tetrahydrate
- baumannii isolates and ATCC 19606 have been decided by pulsed-field gel electrophoresis (PFGE), and colistin MICs have been measured. The time-kill kinetics of colistin towards A. baumannii ATCC 19606 and medical isolate 6 have been investigated, and inhabitants evaluation profiles (PAPs) have been performed. Resistance growth was investigated by serial passaging with or with out publicity to colistin.
- 5 completely different PFGE banding patterns have been discovered within the medical isolates. MICs of colistin towards all isolates have been inside 0.25 to 2 microg/ml. Colistin confirmed early concentration-dependent killing, however bacterial regrowth was noticed at 24 h. PAPs revealed that heteroresistance to colistin occurred in 15 of the 16 medical isolates. Subpopulations (<0.1% from inocula of 10(8) to 10(9) CFU/ml) of ATCC 19606, and most medical isolates grew within the presence of colistin three to 10 microg/ml.
Check- IPL Match Prediction 2021
Ruxolitinib . phosphate salt |
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10-043 | ProSci | 25 mg | EUR 387.96 |
Ruxolitinib . phosphate salt |
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GW4048-100 | Glentham Life Sciences | 100 | EUR 322.4 |
Ruxolitinib . phosphate salt |
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GW4048-25 | Glentham Life Sciences | 25 | EUR 157.3 |
Ruxolitinib . phosphate salt |
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GW4048-5 | Glentham Life Sciences | 5 | EUR 92.4 |
Ruxolitinib, Phosphate |
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27059-1 | BPS Bioscience | 25 mg | EUR 245 |
Ruxolitinib, Phosphate |
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27059-2 | BPS Bioscience | 100 mg | EUR 385 |
Ruxolitinib phosphate |
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A3781-100 | ApexBio | 100 mg | EUR 448.8 |
Ruxolitinib phosphate |
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A3781-25 | ApexBio | 25 mg | EUR 268.8 |
Ruxolitinib phosphate |
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A3781-5 | ApexBio | 5 mg | EUR 157.2 |
Ruxolitinib phosphate |
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A3781-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 135.6 |
Ruxolitinib (phosphate) |
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HY-50858 | MedChemExpress | 5mg | EUR 142.8 |
Ruxolitinib |
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20-abx076799 | Abbexa |
|
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Ruxolitinib |
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HY-50856 | MedChemExpress | 10mM/1mL | EUR 169.2 |
Ruxolitinib (sulfate) |
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HY-50859 | MedChemExpress | 100mg | EUR 622.8 |
EZSolution? Ruxolitinib |
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B2477-5 | Biovision | each | EUR 261.6 |
Ruxolitinib (INCB018424) |
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A3012-100 | ApexBio | 100 mg | EUR 448.8 |
Ruxolitinib (INCB018424) |
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A3012-25 | ApexBio | 25 mg | EUR 268.8 |
Ruxolitinib (INCB018424) |
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A3012-5 | ApexBio | 5 mg | EUR 157.2 |
Ruxolitinib (INCB018424) |
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A3012-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 157.2 |
Ruxolitinib (INCB018424) |
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A3012-S | ApexBio | Evaluation Sample | EUR 97.2 |
INCB018424 (Ruxolitinib) |
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E1KS1378 | EnoGene | 5mg | EUR 625.2 |
Ruxolitinib (free base) |
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10-042 | ProSci | 25 mg | EUR 418.2 |
Ruxolitinib, Free base |
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2139-100 | Biovision | each | Ask for price |
Ruxolitinib, Free base |
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2139-25 | Biovision | each | EUR 639.6 |
Ruxolitinib, Free base |
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2139-5 | Biovision | each | EUR 248.4 |
Ruxolitinib (free base) |
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GW2265-100 | Glentham Life Sciences | 100 | EUR 404.9 |
Ruxolitinib (free base) |
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GW2265-25 | Glentham Life Sciences | 25 | EUR 216.3 |
Ruxolitinib (free base) |
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GW2265-5 | Glentham Life Sciences | 5 | EUR 116.1 |
Ruxolitinib (S enantiomer) |
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HY-50856A | MedChemExpress | 5mg | EUR 408 |
Ruxolitinib (JAK kinase inhibitor) |
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SIH-509-25MG | Stressmarq | 25 mg | EUR 750 |
Ruxolitinib (JAK kinase inhibitor) |
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SIH-509-5MG | Stressmarq | 5 mg | EUR 285.6 |
Tilmicosin phosphate salt |
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GA7223-100 | Glentham Life Sciences | 100 | EUR 108.5 |
Galactose 1-phosphate Potassium salt |
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HY-113143A | MedChemExpress | 50mg | EUR 198 |
Phenyl phosphate disodium salt dihydrate |
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GE1672-100G | Glentham Life Sciences | 100 g | EUR 180 |
Phenyl phosphate disodium salt dihydrate |
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GE1672-10G | Glentham Life Sciences | 10 g | EUR 62.4 |
Phenyl phosphate disodium salt dihydrate |
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GE1672-25G | Glentham Life Sciences | 25 g | EUR 88.8 |
Phenyl phosphate disodium salt dihydrate |
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GE1672-50G | Glentham Life Sciences | 50 g | EUR 118.8 |
Creatine phosphate disodium salt hydrate |
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GE7721-100G | Glentham Life Sciences | 100 g | EUR 399.6 |
Creatine phosphate disodium salt hydrate |
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GE7721-25G | Glentham Life Sciences | 25 g | EUR 180 |
Creatine phosphate disodium salt hydrate |
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GE7721-5G | Glentham Life Sciences | 5 g | EUR 88.8 |
Phenyl phosphate disodium salt dihydrate |
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GE1672-10 | Glentham Life Sciences | 10 | EUR 22.1 |
Phenyl phosphate disodium salt dihydrate |
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GE1672-100 | Glentham Life Sciences | 100 | EUR 118.7 |
Phenyl phosphate disodium salt dihydrate |
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GE1672-25 | Glentham Life Sciences | 25 | EUR 43.5 |
Phenyl phosphate disodium salt dihydrate |
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GE1672-50 | Glentham Life Sciences | 50 | EUR 68.9 |
Creatine phosphate disodium salt hydrate |
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GE7721-100 | Glentham Life Sciences | 100 | EUR 300.5 |
Creatine phosphate disodium salt hydrate |
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GE7721-25 | Glentham Life Sciences | 25 | EUR 118.7 |
Creatine phosphate disodium salt hydrate |
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GE7721-5 | Glentham Life Sciences | 5 | EUR 43.5 |
beta-Cyclodextrin phosphate sodium salt |
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GC6118-100MG | Glentham Life Sciences | 100 mg | EUR 170.4 |
beta-Cyclodextrin phosphate sodium salt |
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GC6118-250MG | Glentham Life Sciences | 250 mg | EUR 264 |
beta-Cyclodextrin phosphate sodium salt |
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GC6118-100 | Glentham Life Sciences | 100 | EUR 110.7 |
beta-Cyclodextrin phosphate sodium salt |
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GC6118-250 | Glentham Life Sciences | 250 | EUR 187.9 |
Dexamethasone 21-phosphate disodium salt |
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GL6086-1G | Glentham Life Sciences | 1 g | EUR 132 |
Dexamethasone 21-phosphate disodium salt |
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GL6086-5G | Glentham Life Sciences | 5 g | EUR 322.8 |
Creatine phosphate, disodium salt, Tetrahydrate |
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CB0128 | Bio Basic | 5g | EUR 85.06 |
4-Methylumbelliferyl phosphate disodium salt |
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GC5745-1G | Glentham Life Sciences | 1 g | EUR 199.2 |
4-Methylumbelliferyl phosphate disodium salt |
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GC5745-250MG | Glentham Life Sciences | 250 mg | EUR 90 |
4-Methylumbelliferyl phosphate disodium salt |
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GC5745-1 | Glentham Life Sciences | 1 | EUR 134.4 |
4-Methylumbelliferyl phosphate disodium salt |
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GC5745-250 | Glentham Life Sciences | 250 | EUR 45.1 |
Glycerol phosphate disodium salt hydrate, 99% |
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GC7456-100G | Glentham Life Sciences | 100 g | EUR 79.2 |
Glycerol phosphate disodium salt hydrate, 99% |
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GC7456-1KG | Glentham Life Sciences | 1 kg | EUR 255.6 |
Glycerol phosphate disodium salt hydrate, 99% |
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GC7456-250G | Glentham Life Sciences | 250 g | EUR 112.8 |
Glycerol phosphate disodium salt hydrate, 99% |
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GC7456-25G | Glentham Life Sciences | 25 g | EUR 55.2 |
Glycerol phosphate disodium salt hydrate, 99% |
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GC7456-500G | Glentham Life Sciences | 500 g | EUR 170.4 |
Glycerol phosphate disodium salt hydrate, 99% |
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GC7456-1 | Glentham Life Sciences | 1 | EUR 182 |
Glycerol phosphate disodium salt hydrate, 99% |
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GC7456-100 | Glentham Life Sciences | 100 | EUR 35.5 |
Glycerol phosphate disodium salt hydrate, 99% |
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GC7456-25 | Glentham Life Sciences | 25 | EUR 15.9 |
Glycerol phosphate disodium salt hydrate, 99% |
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GC7456-250 | Glentham Life Sciences | 250 | EUR 63.3 |
Glycerol phosphate disodium salt hydrate, 99% |
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GC7456-500 | Glentham Life Sciences | 500 | EUR 110.7 |
1-Naphthyl phosphate disodium salt hydrate |
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GE8832-1G | Glentham Life Sciences | 1 g | EUR 103.2 |
1-Naphthyl phosphate disodium salt hydrate |
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GE8832-25G | Glentham Life Sciences | 25 g | EUR 582 |
1-Naphthyl phosphate disodium salt hydrate |
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GE8832-5G | Glentham Life Sciences | 5 g | EUR 208.8 |
1-Naphthyl phosphate disodium salt hydrate |
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GE8832-1 | Glentham Life Sciences | 1 | EUR 55.4 |
1-Naphthyl phosphate disodium salt hydrate |
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GE8832-25 | Glentham Life Sciences | 25 | EUR 450.8 |
1-Naphthyl phosphate disodium salt hydrate |
|||
GE8832-5 | Glentham Life Sciences | 5 | EUR 142.4 |
1-Naphthyl phosphate monosodium salt hydrate |
|||
GE3933-10G | Glentham Life Sciences | 10 g | EUR 187.2 |
1-Naphthyl phosphate monosodium salt hydrate |
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GE3933-1G | Glentham Life Sciences | 1 g | EUR 62.4 |
1-Naphthyl phosphate monosodium salt hydrate |
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GE3933-25G | Glentham Life Sciences | 25 g | EUR 342 |
- 4 successive passages of ATCC 19606 in broth containing colistin (as much as 200 microg/ml) considerably elevated the proportion of the resistant subpopulations capable of develop within the presence of colistin at 10 microg/ml from 0.000023 to 100%; even after 16 passages in colistin-free broth, the proportion solely decreased to 2.1%.
Glucose-6-phosphate, disodium salt, hydrate
- This represents the primary demonstration of straightgeneous colistin-resistant A. baumannii in “colistin-susceptible” medical isolates. Our findings give a powerful warning that colistin-resistant A. baumannii could also be noticed extra ceaselessly resulting from potential suboptimal dosage regimens really useful within the product data of some merchandise of colistin methanesulfonate.