Inhabitants pharmacokinetics of colistin methanesulfonate and shaped colistin in critically sick sufferers from a multicenter examine present dosing solutions for varied classes of sufferers.
- With growing medical emergence of multidrug-resistant Gram-negative pathogens and the paucity of recent brokers to fight these infections, colistin (administered as its inactive prodrug colistin methanesulfonate [CMS]) has reemerged as a remedy choice, particularly for critically sick sufferers.
- There was a dearth of pharmacokinetic (PK) knowledge obtainable to guide dosing in critically sick sufferers, together with these on renal alternative remedy.
HYDROXYSTILBAMIDINE BIS(METHANESULFONATE)
- In an ongoing examine to develop a inhabitants PK mannequin for CMS and colistin, 105 sufferers have been studied so far; these included 12 sufferers on hemodialysis and four on steady renal replacement remedy. For patients not on renal alternative, there was a large variance in creatinine clearance, starting from three to 169 ml/min/1.73 m(2). Every affected person was handled with a physician-selected CMS dosage routine, and eight blood samples for PK evaluation have been collected throughout a dosage interval on day three or four of remedy.
- A linear PK mannequin with two compartments for CMS and one compartment for shaped colistin greatest described the info. Covariates included creatinine clearance on the entire clearance of CMS and colistin, in addition to physique weight on the central quantity of CMS. Mannequin-fitted parameter estimates have been used to derive instructed loading and upkeep dosing regimens for varied classes of sufferers, together with these on hemodialysis and steady renal alternative.
IMATINIB, METHANESULFONATE SALT, >99%
- Primarily based on our present understanding of colistin POkay and pharmacodynamic relationships, colistin could greatest be used as a part of a extremely lively mixture, particularly for sufferers with average to good renal perform and/or for organisms with MICs of ≥ 1.Zero mg/liter.
Imatinib, Methanesulfonate Salt, >99% |
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BC040-101 | GenDepot | 1g | EUR 278.4 |
Imatinib, Methanesulfonate Salt, >99% |
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BC040-102 | GenDepot | 2g | EUR 360 |
Imatinib, Methanesulfonate Salt, >99% |
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BC040-105 | GenDepot | 5g | EUR 505.2 |
Imatinib, Methanesulfonate Salt, >99% |
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BC040-500 | GenDepot | 500mg | Ask for price |
Colistin Methanesulfonate (sodium salt) |
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C3046-1000 | ApexBio | 1 g | EUR 208.8 |
Colistin Methanesulfonate (sodium salt) |
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C3046-5000 | ApexBio | 5 g | EUR 734.4 |
Dabrafenib |
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20-abx182412 | Abbexa |
|
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Dabrafenib |
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D072-10MG | TOKU-E | 10 mg | EUR 159.6 |
Dabrafenib |
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D072-25MG | TOKU-E | 25 mg | EUR 266.4 |
Dabrafenib |
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HY-14660 | MedChemExpress | 100mg | EUR 253.2 |
Dabrafenib (GSK2118436) |
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B1407-10 | ApexBio | 10 mg | EUR 157.2 |
Dabrafenib (GSK2118436) |
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B1407-100 | ApexBio | 100 mg | EUR 393.6 |
Dabrafenib (GSK2118436) |
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B1407-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 135.6 |
Dabrafenib (GSK2118436) |
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B1407-50 | ApexBio | 50 mg | EUR 268.8 |
Dabrafenib (Mesylate) |
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HY-14660A | MedChemExpress | 10mM/1mL | EUR 153.6 |
Pridinol Methanesulfonate |
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A8507-1000 | ApexBio | 1 g | EUR 517.2 |
Pridinol Methanesulfonate |
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A8507-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 129.6 |
Pridinol Methanesulfonate |
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A8507-50 | ApexBio | 50 mg | EUR 153.6 |
Pridinol Methanesulfonate |
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A8507-5000 | ApexBio | 5 g | EUR 1198.8 |
Ethyl methanesulfonate |
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20-abx186442 | Abbexa |
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Abemaciclib (methanesulfonate) |
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HY-16297 | MedChemExpress | 500mg | EUR 542.4 |
Tricaine methanesulfonate |
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GE5936-10G | Glentham Life Sciences | 10 g | EUR 68.4 |
Tricaine methanesulfonate |
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GE5936-25G | Glentham Life Sciences | 25 g | EUR 98.4 |
Tricaine methanesulfonate |
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GE5936-50G | Glentham Life Sciences | 50 g | EUR 141.6 |
Tricaine methanesulfonate |
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GE5936-5G | Glentham Life Sciences | 5 g | EUR 56.4 |
Ethyl methanesulfonate |
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GX0446-100G | Glentham Life Sciences | 100 g | EUR 313.2 |
Ethyl methanesulfonate |
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GX0446-10G | Glentham Life Sciences | 10 g | EUR 88.8 |
Ethyl methanesulfonate |
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GX0446-25G | Glentham Life Sciences | 25 g | EUR 141.6 |
Ethyl methanesulfonate |
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GX0446-5G | Glentham Life Sciences | 5 g | EUR 64.8 |
Silver methanesulfonate |
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GX5020-25G | Glentham Life Sciences | 25 g | EUR 208.8 |
Silver methanesulfonate |
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GX5020-5G | Glentham Life Sciences | 5 g | EUR 85.2 |
Ethyl methanesulfonate |
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S-1930 | Scientific Laboratory Supplies | 1ML | EUR 75.24 |
Dabrafenib Mesylate (GSK-2118436) |
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A3347-10 | ApexBio | 10 mg | EUR 157.2 |
Dabrafenib Mesylate (GSK-2118436) |
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A3347-100 | ApexBio | 100 mg | EUR 393.6 |
Dabrafenib Mesylate (GSK-2118436) |
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A3347-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 150 |
Dabrafenib Mesylate (GSK-2118436) |
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A3347-50 | ApexBio | 50 mg | EUR 268.8 |
Dabrafenib Mesylate (GSK-2118436) |
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A3347-S | ApexBio | Evaluation Sample | EUR 97.2 |
PF-04217903 methanesulfonate |
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A3712-100 | ApexBio | 100 mg | EUR 714 |
PF-04217903 methanesulfonate |
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A3712-25 | ApexBio | 25 mg | EUR 351.6 |
PF-04217903 methanesulfonate |
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A3712-5 | ApexBio | 5 mg | EUR 157.2 |
Tariquidar methanesulfonate, hydrate |
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A3859-10 | ApexBio | 10 mg | EUR 226.8 |
Tariquidar methanesulfonate, hydrate |
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A3859-50 | ApexBio | 50 mg | EUR 532.8 |
2-Chloroethyl methanesulfonate |
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20-abx183170 | Abbexa |
|
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Colistin Sodium Methanesulfonate |
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C073-10G | TOKU-E | 10 g | EUR 984 |
Colistin Sodium Methanesulfonate |
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C073-1G | TOKU-E | 1 g | EUR 162 |
Colistin Sodium Methanesulfonate |
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C073-5G | TOKU-E | 5 g | EUR 528 |
BCX 1470 (methanesulfonate) |
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HY-50875 | MedChemExpress | 10mM/1mL | EUR 696 |
Colistin sodium methanesulfonate |
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GA2961-1G | Glentham Life Sciences | 1 g | EUR 151.2 |
Colistin sodium methanesulfonate |
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GA2961-5G | Glentham Life Sciences | 5 g | EUR 351.6 |
Tariquidar (methanesulfonate, hydrate) |
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HY-10550A | MedChemExpress | 100mg | EUR 734.4 |
Hydroxystilbamidine bis(methanesulfonate) |
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HY-108166A | MedChemExpress | 5mg | EUR 639.6 |
PF-06424439 (methanesulfonate) |
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HY-108341A | MedChemExpress | 10mM/1mL | EUR 175.2 |
PF-04217903 (methanesulfonate) |
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HY-12017A | MedChemExpress | 10mM/1mL | EUR 187.2 |
Ethyl 3-Aminobenzoate (methanesulfonate) |
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C3619-100000 | ApexBio | 100 g | EUR 381.6 |
Ethyl 3-Aminobenzoate (methanesulfonate) |
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C3619-25000 | ApexBio | 25 g | EUR 153.6 |
Ethyl 3-Aminobenzoate (methanesulfonate) |
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C3619-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 135.6 |
Ethyl 3-Aminobenzoate (methanesulfonate) |
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C3619-50000 | ApexBio | 50 g | EUR 234 |
Ro 31-8220 methanesulfonate |
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1946-1 | Biovision | each | EUR 164.4 |
Ro 31-8220 methanesulfonate |
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1946-5 | Biovision | each | EUR 457.2 |
Pesticide Std Ethyl methanesulfonate Neat |
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REPET352N | Scientific Laboratory Supplies | 10MG | EUR 72.96 |
Pesticide Std Methyl Methanesulfonate Neat |
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REPET374N | Scientific Laboratory Supplies | 10MG | EUR 72.96 |
Pesticide Std Ethyl methanesulfonate 1000ug/mL in MeOH |
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REPET352 | Scientific Laboratory Supplies | 1ML | EUR 88.92 |
Pesticide Std Ethyl methanesulfonate 2000ug/mL in MeOH |
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REPET353 | Scientific Laboratory Supplies | 1ML | EUR 99.18 |
Pesticide Std Methyl Methanesulfonate 1000ug/mL in MeOH |
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REPET374 | Scientific Laboratory Supplies | 1ML | EUR 98.04 |
Pesticide Std Methyl Methanesulfonate 2000ug/mL in MeOH |
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REPET375 | Scientific Laboratory Supplies | 1ML | EUR 94.62 |
Bile salt |
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BB0225 | Bio Basic | 25g | EUR 95.5 |
Mannitol Salt |
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254027 | Scientific Laboratory Supplies | PK20 | EUR 13.68 |
Rosuvastatin . calcium salt |
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10-041 | ProSci | 250 mg | EUR 478.68 |
Ruxolitinib . phosphate salt |
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10-043 | ProSci | 25 mg | EUR 387.96 |
Thyroxine (Sodium salt) |
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30-AT52 | Fitzgerald | 1 gram | EUR 422.4 |
Triiodothyronine (Sodium salt) |
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30-AT53 | Fitzgerald | 1 gram | EUR 1018.8 |
Carbenicillin, Disodium Salt |
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A2511-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 129.6 |
Carbenicillin, Disodium Salt |
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A2511-50 | ApexBio | 50 mg | EUR 157.2 |
CYT387 sulfate salt |
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A3339-10 | ApexBio | 10 mg | EUR 212.4 |
Heteroresistance to colistin in multidrug-resistant Acinetobacter baumannii.
- Multidrug-resistant Acinetobacter baumannii has emerged as a major medical downside worldwide and colistin is getting used more and more as “salvage” remedy. MICs of colistin towards A. baumannii point out its vital exercise. Nonetheless, resistance to colistin in A. baumannii has been reported just lately. Clonotypes of 16 medical A.
Creatine phosphate, disodium salt, Tetrahydrate
- baumannii isolates and ATCC 19606 have been decided by pulsed-field gel electrophoresis (PFGE), and colistin MICs have been measured. The time-kill kinetics of colistin towards A. baumannii ATCC 19606 and medical isolate 6 have been investigated, and inhabitants evaluation profiles (PAPs) have been performed. Resistance growth was investigated by serial passaging with or with out publicity to colistin.
- 5 completely different PFGE banding patterns have been discovered within the medical isolates. MICs of colistin towards all isolates have been inside 0.25 to 2 microg/ml. Colistin confirmed early concentration-dependent killing, however bacterial regrowth was noticed at 24 h. PAPs revealed that heteroresistance to colistin occurred in 15 of the 16 medical isolates. Subpopulations (<0.1% from inocula of 10(8) to 10(9) CFU/ml) of ATCC 19606, and most medical isolates grew within the presence of colistin three to 10 microg/ml.
Check- IPL Match Prediction 2021
Ruxolitinib . phosphate salt |
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10-043 | ProSci | 25 mg | EUR 387.96 |
Ruxolitinib phosphate |
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A3781-100 | ApexBio | 100 mg | EUR 448.8 |
Ruxolitinib phosphate |
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A3781-25 | ApexBio | 25 mg | EUR 268.8 |
Ruxolitinib phosphate |
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A3781-5 | ApexBio | 5 mg | EUR 157.2 |
Ruxolitinib phosphate |
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A3781-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 135.6 |
Ruxolitinib (phosphate) |
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HY-50858 | MedChemExpress | 5mg | EUR 142.8 |
Ruxolitinib, Phosphate |
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27059-1 | BPS Bioscience | 25 mg | EUR 245 |
Ruxolitinib, Phosphate |
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27059-2 | BPS Bioscience | 100 mg | EUR 385 |
Ruxolitinib |
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20-abx076799 | Abbexa |
|
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Ruxolitinib |
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HY-50856 | MedChemExpress | 10mM/1mL | EUR 169.2 |
Ruxolitinib (INCB018424) |
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A3012-100 | ApexBio | 100 mg | EUR 448.8 |
Ruxolitinib (INCB018424) |
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A3012-25 | ApexBio | 25 mg | EUR 268.8 |
Ruxolitinib (INCB018424) |
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A3012-5 | ApexBio | 5 mg | EUR 157.2 |
Ruxolitinib (INCB018424) |
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A3012-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 157.2 |
Ruxolitinib (INCB018424) |
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A3012-S | ApexBio | Evaluation Sample | EUR 97.2 |
INCB018424 (Ruxolitinib) |
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E1KS1378 | EnoGene | 5mg | EUR 625.2 |
Ruxolitinib (sulfate) |
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HY-50859 | MedChemExpress | 100mg | EUR 622.8 |
EZSolution? Ruxolitinib |
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B2477-5 | Biovision | each | EUR 261.6 |
Creatine phosphate, disodium salt, Tetrahydrate |
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CB0128 | Bio Basic | 5g | EUR 85.06 |
Dexamethasone 21-phosphate disodium salt |
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GL6086-1G | Glentham Life Sciences | 1 g | EUR 132 |
Dexamethasone 21-phosphate disodium salt |
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GL6086-5G | Glentham Life Sciences | 5 g | EUR 322.8 |
4-Methylumbelliferyl phosphate disodium salt |
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GC5745-1G | Glentham Life Sciences | 1 g | EUR 199.2 |
4-Methylumbelliferyl phosphate disodium salt |
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GC5745-250MG | Glentham Life Sciences | 250 mg | EUR 90 |
beta-Cyclodextrin phosphate sodium salt |
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GC6118-100MG | Glentham Life Sciences | 100 mg | EUR 170.4 |
beta-Cyclodextrin phosphate sodium salt |
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GC6118-250MG | Glentham Life Sciences | 250 mg | EUR 264 |
Phenyl phosphate disodium salt dihydrate |
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GE1672-100G | Glentham Life Sciences | 100 g | EUR 180 |
Phenyl phosphate disodium salt dihydrate |
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GE1672-10G | Glentham Life Sciences | 10 g | EUR 62.4 |
Phenyl phosphate disodium salt dihydrate |
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GE1672-25G | Glentham Life Sciences | 25 g | EUR 88.8 |
Phenyl phosphate disodium salt dihydrate |
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GE1672-50G | Glentham Life Sciences | 50 g | EUR 118.8 |
Creatine phosphate disodium salt hydrate |
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GE7721-100G | Glentham Life Sciences | 100 g | EUR 399.6 |
Creatine phosphate disodium salt hydrate |
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GE7721-25G | Glentham Life Sciences | 25 g | EUR 180 |
Creatine phosphate disodium salt hydrate |
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GE7721-5G | Glentham Life Sciences | 5 g | EUR 88.8 |
Galactose 1-phosphate Potassium salt |
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HY-113143A | MedChemExpress | 50mg | EUR 198 |
Ruxolitinib (free base) |
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10-042 | ProSci | 25 mg | EUR 418.2 |
S-Ruxolitinib (INCB018424) |
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A4149-1 | ApexBio | 1 mg | EUR 277.2 |
S-Ruxolitinib (INCB018424) |
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A4149-5 | ApexBio | 5 mg | EUR 514.8 |
S-Ruxolitinib (INCB018424) |
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A4149-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 367.2 |
Ruxolitinib (S enantiomer) |
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HY-50856A | MedChemExpress | 5mg | EUR 408 |
Ruxolitinib, Free base |
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2139-100 | Biovision | each | Ask for price |
Ruxolitinib, Free base |
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2139-25 | Biovision | each | EUR 639.6 |
Ruxolitinib, Free base |
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2139-5 | Biovision | each | EUR 248.4 |
D-Glucose-6-phosphate disodium salt |
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20-abx180718 | Abbexa |
|
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4-Nitrophenyl phosphate disodium salt hexahydrate |
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CSUB-0027 | Creative Enzymes | 4g | EUR 324 |
beta-Glycerol phosphate disodium salt pentahydrate |
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GK9068-25G | Glentham Life Sciences | 25 g | EUR 64.8 |
Riboflavin-5'-phosphate monosodium salt hydrate |
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GP6544-100G | Glentham Life Sciences | 100 g | EUR 228 |
Riboflavin-5'-phosphate monosodium salt hydrate |
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GP6544-250G | Glentham Life Sciences | 250 g | EUR 380.4 |
Riboflavin-5'-phosphate monosodium salt hydrate |
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GP6544-25G | Glentham Life Sciences | 25 g | EUR 112.8 |
Riboflavin-5'-phosphate monosodium salt hydrate |
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GP6544-5G | Glentham Life Sciences | 5 g | EUR 69.6 |
Glucose-6-phosphate, disodium salt, hydrate |
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GB0481 | Bio Basic | 1g | EUR 89.23 |
D-Glucose-6-phosphate monosodium salt |
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GC0472-1G | Glentham Life Sciences | 1 g | EUR 151.2 |
D-Glucose-6-phosphate monosodium salt |
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GC0472-500MG | Glentham Life Sciences | 500 mg | EUR 97.2 |
D-Fructose-6-phosphate disodium salt |
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GC1944-1G | Glentham Life Sciences | 1 g | EUR 175.2 |
4-Nitrophenyl phosphate disodium salt hexahydrate |
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GC2733-25G | Glentham Life Sciences | 25 g | EUR 122.4 |
4-Nitrophenyl phosphate disodium salt hexahydrate |
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GC2733-5G | Glentham Life Sciences | 5 g | EUR 74.4 |
Glycerol-1-phosphate magnesium salt hydrate |
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GC3404-100G | Glentham Life Sciences | 100 g | EUR 84 |
Glycerol-1-phosphate magnesium salt hydrate |
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GC3404-1KG | Glentham Life Sciences | 1 kg | EUR 322.8 |
Glycerol-1-phosphate magnesium salt hydrate |
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GC3404-250G | Glentham Life Sciences | 250 g | EUR 132 |
Glycerol-1-phosphate magnesium salt hydrate |
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GC3404-500G | Glentham Life Sciences | 500 g | EUR 204 |
Glycerol phosphate disodium salt hydrate, 99% |
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GC7456-100G | Glentham Life Sciences | 100 g | EUR 79.2 |
Glycerol phosphate disodium salt hydrate, 99% |
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GC7456-1KG | Glentham Life Sciences | 1 kg | EUR 255.6 |
Glycerol phosphate disodium salt hydrate, 99% |
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GC7456-250G | Glentham Life Sciences | 250 g | EUR 112.8 |
Glycerol phosphate disodium salt hydrate, 99% |
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GC7456-25G | Glentham Life Sciences | 25 g | EUR 55.2 |
Glycerol phosphate disodium salt hydrate, 99% |
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GC7456-500G | Glentham Life Sciences | 500 g | EUR 170.4 |
D-Glucose-6-phosphate disodium salt |
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GC9849-10MG | Glentham Life Sciences | 10 mg | EUR 50.4 |
D-Glucose-6-phosphate disodium salt |
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GC9849-1G | Glentham Life Sciences | 1 g | EUR 74.4 |
D-Glucose-6-phosphate disodium salt |
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GC9849-25G | Glentham Life Sciences | 25 g | EUR 657.6 |
D-Glucose-6-phosphate disodium salt |
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GC9849-500MG | Glentham Life Sciences | 500 mg | EUR 64.8 |
D-Glucose-6-phosphate disodium salt |
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GC9849-5G | Glentham Life Sciences | 5 g | EUR 208.8 |
1-Naphthyl phosphate monosodium salt hydrate |
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GE3933-10G | Glentham Life Sciences | 10 g | EUR 187.2 |
1-Naphthyl phosphate monosodium salt hydrate |
|||
GE3933-1G | Glentham Life Sciences | 1 g | EUR 62.4 |
1-Naphthyl phosphate monosodium salt hydrate |
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GE3933-25G | Glentham Life Sciences | 25 g | EUR 342 |
1-Naphthyl phosphate monosodium salt hydrate |
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GE3933-5G | Glentham Life Sciences | 5 g | EUR 122.4 |
1-Naphthyl phosphate disodium salt hydrate |
|||
GE8832-1G | Glentham Life Sciences | 1 g | EUR 103.2 |
1-Naphthyl phosphate disodium salt hydrate |
|||
GE8832-25G | Glentham Life Sciences | 25 g | EUR 582 |
1-Naphthyl phosphate disodium salt hydrate |
|||
GE8832-5G | Glentham Life Sciences | 5 g | EUR 208.8 |
β-Glycerol phosphate (disodium salt pentahydrate) |
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HY-D0886 | MedChemExpress | 500mg | EUR 129.6 |
Riboflavin-5-phosphate, sodium salt, dihydrate |
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RD0472 | Bio Basic | 25g | EUR 87.14 |
- 4 successive passages of ATCC 19606 in broth containing colistin (as much as 200 microg/ml) considerably elevated the proportion of the resistant subpopulations capable of develop within the presence of colistin at 10 microg/ml from 0.000023 to 100%; even after 16 passages in colistin-free broth, the proportion solely decreased to 2.1%.
Glucose-6-phosphate, disodium salt, hydrate
- This represents the primary demonstration of straightgeneous colistin-resistant A. baumannii in “colistin-susceptible” medical isolates. Our findings give a powerful warning that colistin-resistant A. baumannii could also be noticed extra ceaselessly resulting from potential suboptimal dosage regimens really useful within the product data of some merchandise of colistin methanesulfonate.